AZ3137 is an orally Bioavailable Androgen Receptor Degrader (IC50 = 22 nM) for the Treatment of Prostate Cancer. AZ3137 possessed an attractive profile showing degradation of AR and L702H mutant AR with good oral bioavailability across species. The compound also inhibited AR signaling in vitro and tumor growth in vivo in a mouse prostate cancer xenograft model.
MedKoo Cat#: 127409
Name: AZ3137
CAS#: N/A
Chemical Formula: C43H47F4N7O4
Exact Mass: 801.3626
Molecular Weight: 801.89
Elemental Analysis: C, 64.41; H, 5.91; F, 9.48; N, 12.23; O, 7.98
The following data is based on the product molecular weight 801.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
