MedKoo Cat#: 208164 | Name: SRI-37264

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SRI-37264 is part of Src-family tyrosine kinase Hck, which enhances the HIV-1 life cycle in macrophages. Nef inhibitors in this class have the potential to block HIV-1 replication in myeloid cells and trigger recognition of HIV-infected cells by the adaptive immune system in vivo.

Chemical Structure

SRI-37264
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208164

Name: SRI-37264

CAS#: unknown

Chemical Formula: C17H14ClN3O3S

Exact Mass: 375.0444

Molecular Weight: 375.83

Elemental Analysis: C, 54.33; H, 3.75; Cl, 9.43; N, 11.18; O, 12.77; S, 8.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SRI 37264, SRI37264
IUPAC/Chemical Name
2-(4-Chloro-3-(morpholine-4-carbonyl)phenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
InChi Key
MZBFJSQDRFBYKT-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14ClN3O3S/c18-14-4-3-11(10-13(14)16(22)20-6-8-24-9-7-20)21-17(23)12-2-1-5-19-15(12)25-21/h1-5,10H,6-9H2
SMILES Code
O=C1N(C2=CC=C(Cl)C(C(N3CCOCC3)=O)=C2)SC4=NC=CC=C41
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 375.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
ACS Infect. Dis. 2022, 8, 1, 91–105 Publication Date:January 5, 2022 https://doi.org/10.1021/acsinfecdis.1c00288 Copyright © 2022 American Chemical Society