MedKoo Cat#: 564169 | Name: CDK9-PROTAC
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDK9-PROTAC, also kn own as PROTAC CDK9 Degrader-1, is a cereblon mediated proteasomal degrader of CDK9.

Chemical Structure

CDK9-PROTAC
CDK9-PROTAC
CAS#2118356-96-8

Theoretical Analysis

MedKoo Cat#: 564169

Name: CDK9-PROTAC

CAS#: 2118356-96-8

Chemical Formula: C33H35N5O7

Exact Mass: 613.2536

Molecular Weight: 613.67

Elemental Analysis: C, 64.59; H, 5.75; N, 11.41; O, 18.25

Price and Availability

Size Price Availability Quantity
5mg USD 650.00 2 Weeks
10mg USD 1,060.00 2 Weeks
25mg USD 1,950.00 2 Weeks
500mg USD 4,650.00 2 Weeks
1g USD 6,450.00 2 Weeks
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Related CAS #
Synonym
CDK9PROTAC; CDK9 PROTAC; CDK9-PROTAC; PROTAC CDK9 Degrader-1;
IUPAC/Chemical Name
N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-(4-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)oxy)phenyl)acetamide
InChi Key
WCEHIDWONYOKOJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H35N5O7/c39-28-15-14-25(31(41)35-28)38-32(42)23-8-5-9-26(30(23)33(38)43)45-17-3-1-2-16-44-22-12-10-20(11-13-22)18-29(40)34-27-19-24(36-37-27)21-6-4-7-21/h5,8-13,19,21,25H,1-4,6-7,14-18H2,(H,35,39,41)(H2,34,36,37,40)
SMILES Code
O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(OCCCCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 613.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Luo CH, Hu LH, Liu JY, Xia L, Zhou L, Sun RH, Lin CC, Qiu X, Jiang B, Yang MY, Zhang XH, Yang XB, Chen GQ, Lu Y. CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma. Nat Commun. 2024 Dec 5;15(1):10594. doi: 10.1038/s41467-024-54354-3. PMID: 39632829; PMCID: PMC11618697.