MON06804, also known as (S,R,S)-AHPC-PEG3-azide, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be sued to more quickly generate ProTAC libraries that feature in variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 121198
Name: MON06804
CAS#: 1797406-80-4
Chemical Formula: C30H43N7O7S
Exact Mass: 645.2945
Molecular Weight: 645.78
Elemental Analysis: C, 55.80; H, 6.71; N, 15.18; O, 17.34; S, 4.96
The following data is based on the product molecular weight 645.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
