GAS41 inhibitor 19| CAS# unknown| Inhibitor

MedKoo Cat#: 208149 | Name: GAS41 inhibitor 19

Description:

WARNING: This product is for research use only, not for human or veterinary use.

We found that GAS41 is overexpressed in human pancreatic cancer tissues and cell lines, and that its expression increases following the acquisition of GEM resistance. GAS41 binds to H2A.Z.2 and activates Notch and its downstream mediators, thereby regulating stemness and drug resistance. Depletion of GAS41 or H2A.Z.2 was found to down-regulate Notch and to sensitize pancreatic cancer cells to GEM

Chemical Structure

GAS41 inhibitor 19

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208149

Name: GAS41 inhibitor 19

CAS#: unknown

Chemical Formula: C44H46N8O6S4

Exact Mass: 910.2423

Molecular Weight: 911.14

Elemental Analysis: C, 58.00; H, 5.09; N, 12.30; O, 10.54; S, 14.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GAS41-inhibitor 19, GAS41 inhibitor-19, GAS41-inhibitor-19

IUPAC/Chemical Name

(2S,2'S,4R,4'R)-4,4'-(Butane-1,4-diylbis(oxy))bis(N-(5-(3-(benzo[d]thiazol-2-yl)azetidine-1-carbonyl)thiophen-2-yl)pyrrolidine-2-carboxamide)

InChi Key

NUHGUBQPLSCLGP-CKROWEISSA-N

InChi Code

InChI=1S/C44H46N8O6S4/c53-39(49-37-13-11-35(59-37)43(55)51-21-25(22-51)41-47-29-7-1-3-9-33(29)61-41)31-17-27(19-45-31)57-15-5-6-16-58-28-18-32(46-20-28)40(54)50-38-14-12-36(60-38)44(56)52-23-26(24-52)42-48-30-8-2-4-10-34(30)62-42/h1-4,7-14,25-28,31-32,45-46H,5-6,15-24H2,(H,49,53)(H,50,54)/t27-,28-,31+,32+/m1/s1

SMILES Code

O=C([C@H]1NC[C@H](OCCCCO[C@@H]2C[C@@H](C(NC3=CC=C(C(N4CC(C5=NC6=CC=CC=C6S5)C4)=O)S3)=O)NC2)C1)NC7=CC=C(C(N8CC(C9=NC%10=CC=CC=C%10S9)C8)=O)S7

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 911.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Han, S., Cao, C., Liu, R. et al. GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. Cell Oncol. 45, 429–446 (2022). https://doi.org/10.1007/s13402-022-00675-8