MedKoo Cat#: 130483 | Name: SA-15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SA-15 is a novel inhibitor of lymphocyte activation gene 3 (LAG-3), inhibiting both LAG-3/MHCII and LAG-3/FGL1 interactions in biochemical binding assays with IC50 values of 14.81 ± 0.92 and 16.67 ± 1.42 μM, respectively.

Chemical Structure

SA-15
SA-15
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130483

Name: SA-15

CAS#: N/A

Chemical Formula: C20H20N2O4

Exact Mass: 352.1423

Molecular Weight: 352.39

Elemental Analysis: C, 68.17; H, 5.72; N, 7.95; O, 18.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SA15, SA 15
IUPAC/Chemical Name
N-(4-(2-Oxo-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)ethoxy)phenyl)furan-2-carboxamide
InChi Key
CJFUNOZKJRXQEH-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20N2O4/c1-13-11-17(14(2)22(13)3)18(23)12-26-16-8-6-15(7-9-16)21-20(24)19-5-4-10-25-19/h4-11H,12H2,1-3H3,(H,21,24)
SMILES Code
O=C(C1=CC=CO1)NC2=CC=C(OCC(C3=C(C)N(C)C(C)=C3)=O)C=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 352.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Abdel-Rahman SA, Rehman AU, Gabr MT. Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3). ACS Med Chem Lett. 2023 Apr 11;14(5):629-635. doi: 10.1021/acsmedchemlett.3c00054. PMID: 37197466; PMCID: PMC10184155. 2. Thomsen IP, Sapparapu G, James DBA, Cassat JE, Nagarsheth M, Kose N, Putnam N, Boguslawski KM, Jones LS, Wood JB, Creech CB, Torres VJ, Crowe JE Jr. Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action. J Infect Dis. 2017 Apr 1;215(7):1124-1131. doi: 10.1093/infdis/jix071. PMID: 28186295; PMCID: PMC5426380.