Synonym
SG-094; SG 094; SG094
IUPAC/Chemical Name
6-methoxy-2-methyl-7-phenoxy-1-(4-phenoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
InChi Key
BTNHPUSFPKFAPU-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H29NO3/c1-31-18-17-23-20-29(32-2)30(34-25-11-7-4-8-12-25)21-27(23)28(31)19-22-13-15-26(16-14-22)33-24-9-5-3-6-10-24/h3-16,20-21,28H,17-19H2,1-2H3
SMILES Code
CN1C(CC2=CC=C(OC3=CC=CC=C3)C=C2)C4=CC(OC5=CC=CC=C5)=C(OC)C=C4CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
451.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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Chi G, Jaślan D, Kudrina V, Böck J, Li H, Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M, Bracher F, Grimm C, Dürr KL. Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist. Structure. 2024 Aug 8;32(8):1137-1149.e4. doi: 10.1016/j.str.2024.05.005. Epub 2024 May 29. PMID: 38815576.
Shimomura T. Descending to inhibit: Antagonist-induced downward shift of VSD II in TPC2. Structure. 2024 Aug 8;32(8):1025-1027. doi: 10.1016/j.str.2024.07.005. PMID: 39121835.
