MedKoo Cat#: 208095 | Name: NDI-10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NDI-10 is a novel G4-DNA ligand that promotes transcription in Gram-positive bacteria and represses transcription in Gram-negative bacteria.

Chemical Structure

NDI-10
NDI-10
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208095

Name: NDI-10

CAS#: N/A

Chemical Formula: C34H34F6N6O8

Exact Mass: 768.2342

Molecular Weight:

Elemental Analysis: 768.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NDI-10; NDI 10; NDI10
IUPAC/Chemical Name
2,7-bis(3-(dimethylamino)propyl)-9,14-dihydro-[3,8]phenanthrolino[1,10-abc]phenazine-1,3,6,8(2H,7H)-tetraone bis(2,2,2-trifluoroacetate)
InChi Key
HHTRNPJQROWTKB-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H32N6O4.2C2HF3O2/c1-33(2)13-7-15-35-27(37)17-11-12-18-22-21(17)23(29(35)39)25-26(32-20-10-6-5-9-19(20)31-25)24(22)30(40)36(28(18)38)16-8-14-34(3)4;2*3-2(4,5)1(6)7/h5-6,9-12,31-32H,7-8,13-16H2,1-4H3;2*(H,6,7)
SMILES Code
O=C(N(CCCN(C)C)C1=O)C2=CC=C3C4=C(C(N(CCCN(C)C)C3=O)=O)C5=C(NC(C=CC=C6)=C6N5)C1=C24.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Cebrián R, Belmonte-Reche E, Pirota V, de Jong A, Morales JC, Freccero M, Doria F, Kuipers OP. G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. J Med Chem. 2022 Mar 24;65(6):4752-4766. doi: 10.1021/acs.jmedchem.1c01905. Epub 2021 Dec 20. PMID: 34928608; PMCID: PMC8958502. 2. Lai CH, Muhammad S, Al-Sehemi AG, Chaudhry AR. A systematic study of the effects of thionation in naphthalene dimide derivatives to tune their nonlinear optical properties. J Mol Graph Model. 2019 Mar;87:68-75. doi: 10.1016/j.jmgm.2018.11.010. Epub 2018 Nov 26. PMID: 30503996. 3. Boody BS, Bhatt S, Mazmudar AS, Hsu WK, Rothrock NE, Patel AA. Validation of Patient-Reported Outcomes Measurement Information System (PROMIS) computerized adaptive tests in cervical spine surgery. J Neurosurg Spine. 2018 Mar;28(3):268-279. doi: 10.3171/2017.7.SPINE17661. Epub 2018 Jan 5. PMID: 29303468; PMCID: PMC7315645.