MedKoo Cat#: 564327 | Name: MB710
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MB710 is a Y220C stabilizer which stabilizes the thermolabile p53 cancer mutant Y220C and shows anticancer activity in p53-Y220C cell lines.

Chemical Structure

MB710
MB710
CAS#2230044-57-0

Theoretical Analysis

MedKoo Cat#: 564327

Name: MB710

CAS#: 2230044-57-0

Chemical Formula: C16H16IN3O3S

Exact Mass: 456.9957

Molecular Weight: 457.29

Elemental Analysis: C, 42.03; H, 3.53; I, 27.75; N, 9.19; O, 10.50; S, 7.01

Price and Availability

Size Price Availability Quantity
5mg USD 875.00 2 Weeks
10mg USD 1,475.00 2 Weeks
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Related CAS #
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Synonym
MB-710; MB 710; MB710
IUPAC/Chemical Name
2-(Diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxylic acid
InChi Key
SEBJATZOIHUGAU-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H16IN3O3S/c1-3-19(4-2)16-18-11-9(15(22)23)13(21)10(17)12(14(11)24-16)20-7-5-6-8-20/h5-8,21H,3-4H2,1-2H3,(H,22,23)
SMILES Code
O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baud MGJ, Bauer MR, Verduci L, Dingler FA, Patel KJ, Horil Roy D, Joerger AC, Fersht AR. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114. doi: 10.1016/j.ejmech.2018.04.035. Epub 2018 Apr 21. PubMed PMID: 29702446; PubMed Central PMCID: PMC5986712.