Acoramidis, also known as AG-10. is novel, potent, highly selective, orally bioavailable transthyretin (TTR) stabilizer with potential disease-modifying activity. AG-10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. AG10 has been shown to stabilize Transthyretin (TTR or TBPA) --- a transport protein in serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol --- in Symptomatic Transthyretin Amyloid Cardiomyopathy. In this way, AG10 mimics a naturally occurring genetic variant, T119M, that protects from Transthyretin Amyloidosis.
MedKoo Cat#: 208077
Name: Acoramidis free base
CAS#: 1446711-81-4 (free base)
Chemical Formula: C15H17FN2O3
Exact Mass: 292.1223
Molecular Weight: 292.31
Elemental Analysis: C, 61.63; H, 5.86; F, 6.50; N, 9.58; O, 16.42
The following data is based on the product molecular weight 292.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
