NNC-55-0396 | CAS# 357400-14-7 | Biochemical

MedKoo Cat#: 578252 | Name: NNC-55-0396

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NNC-55-0396 is a T-type calcium channel blocker.

Chemical Structure

NNC-55-0396

CAS#357400-14-7

Theoretical Analysis

MedKoo Cat#: 578252

Name: NNC-55-0396

CAS#: 357400-14-7

Chemical Formula: C30H38FN3O2

Exact Mass: 491.2948

Molecular Weight: 491.65

Elemental Analysis: C, 73.29; H, 7.79; F, 3.86; N, 8.55; O, 6.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NNC-55-0396; NNC 55-0396; NNC55-0396

IUPAC/Chemical Name

Cyclopropanecarboxylic acid, (1S,2S)-2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester

InChi Key

VHHVPDKNKPNKHY-JDXGNMNLSA-N

InChi Code

InChI=1S/C30H38FN3O2/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27/h4-5,7-8,12-13,19-21,28H,6,9-11,14-18H2,1-3H3,(H,32,33)/t28-,30-/m0/s1

SMILES Code

CC(C)[C@H]1c2ccc(F)cc2CC[C@@]1(CCN(C)CCCc3nc4ccccc4[nH]3)OC(=O)C5CC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 491.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang W, Lu C, Wu Y, Ouyang S, Chen Y. T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines. J Exp Clin Cancer Res. 2015 May 21;34:54. doi: 10.1186/s13046-015-0171-4. PubMed PMID: 25989794; PubMed Central PMCID: PMC4443536. 2: Fernández-Morales JC, Fernando Padín J, Vestring S, Musial DC, de Diego AM, García AG. Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life. Eur J Pharmacol. 2015 Mar 15;751:1-12. doi: 10.1016/j.ejphar.2015.01.025. Epub 2015 Jan 23. PubMed PMID: 25622555. 3: Kim KH, Kim D, Park JY, Jung HJ, Cho YH, Kim HK, Han J, Choi KY, Kwon HJ. NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction. J Mol Med (Berl). 2015 May;93(5):499-509. doi: 10.1007/s00109-014-1235-1. Epub 2014 Dec 4. PubMed PMID: 25471482. 4: Son YK, Hong da H, Li H, Kim DJ, Na SH, Park H, Jung WK, Choi IW, Park WS. Ca2+ channel inhibitor NNC 55-0396 inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. J Pharmacol Sci. 2014;125(3):312-9. Epub 2014 Jul 1. PubMed PMID: 24989838.