MedKoo Cat#: 578138 | Name: Nicaraven dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nicaraven dihydrochloride is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.

Chemical Structure

Nicaraven dihydrochloride
Nicaraven dihydrochloride
CAS#1158520-62-7 (2HCl)

Theoretical Analysis

MedKoo Cat#: 578138

Name: Nicaraven dihydrochloride

CAS#: 1158520-62-7 (2HCl)

Chemical Formula: C15H18Cl2N4O2

Exact Mass: 356.0807

Molecular Weight: 357.23

Elemental Analysis: C, 50.43; H, 5.08; Cl, 19.85; N, 15.68; O, 8.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Nicaraven dihydrochloride; Nicaraven 2HCl
IUPAC/Chemical Name
3-Pyridinecarboxamide, N,N'-(1-methyl-1,2-ethanediyl)bis-, dihydrochloride
InChi Key
OBORDVXFXYGFAV-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H16N4O2.2ClH/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12;;/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21);2*1H
SMILES Code
Cl.Cl.CC(CNC(=O)c1cccnc1)NC(=O)c2cccnc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. Biochem Biophys Res Commun. 2014 Sep 26;452(3):548-53. doi: 10.1016/j.bbrc.2014.08.112. PubMed PMID: 25173934. 2: Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. doi: 10.1371/journal.pone.0060023. PubMed PMID: 23555869; PubMed Central PMCID: PMC3612087. 3: Shimada Y, Tsunoda H, Zang L, Hirano M, Oka T, Tanaka T. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Eur J Pharmacol. 2009 Oct 12;620(1-3):16-20. doi: 10.1016/j.ejphar.2009.08.009. PubMed PMID: 19686725. 4: Watanabe M, Akiyama N, Sekine H, Mori M, Manome Y. Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7. PubMed PMID: 17094462. 5: Katayama Y, Igarashi H. [Advances in the diagnosis and treatment of cerebral ischemia during the acute phase]. Rinsho Shinkeigaku. 2003 Nov;43(11):887-90. Review. Japanese. PubMed PMID: 15152494. 6: Yoshinaga H, Watanabe M, Manome Y. Possible role of nicaraven in neuroprotective effect on hippocampal slice culture. Can J Physiol Pharmacol. 2003 Jul;81(7):683-9. PubMed PMID: 12897815. 7: Leker RR. Nicaraven Chugai. Curr Opin Investig Drugs. 2003 Jan;4(1):83-90. Review. PubMed PMID: 12625035. 8: Naritomi H. [Neuroprotective therapy for the treatment of acute ischemic stroke]. Rinsho Shinkeigaku. 2001 Dec;41(12):1060-3. Review. Japanese. PubMed PMID: 12235795. 9: Longo M, Blandino A, Ascenti G, Ricciardi GK, Granata F, Vinci S. Cerebral angiography in the rat with mammographic equipment: a simple, cost-effective method for assessing vasospasm in experimental subarachnoid haemorrhage. Neuroradiology. 2002 Aug;44(8):689-94. PubMed PMID: 12185547. 10: Jain KK. Nicaraven for the treatment of cerebral vasospasm in subarachnoid haemorrhage. Expert Opin Investig Drugs. 2000 Apr;9(4):859-70. Review. PubMed PMID: 11060715. 11: Yokota R, Fukai M, Shimamura T, Suzuki T, Watanabe Y, Nagashima K, Kishida A, Furukawa H, Hayashi T, Todo S. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery. 2000 Jun;127(6):661-9. PubMed PMID: 10840362. 12: Yamamoto S, Teng W, Nishizawa S, Kakiuchi T, Tsukada H. Improvement in cerebral blood flow and metabolism following subarachnoid hemorrhage in response to prophylactic administration of the hydroxyl radical scavenger, AVS, (+/-)-N,N'-propylenedinicotinamide: a positron emission tomography study in rats. J Neurosurg. 2000 Jun;92(6):1009-15. PubMed PMID: 10839263. 13: Akimoto T. Quantitative analysis of the kinetic constant of the reaction of N,N'-propylenedinicotinamide with the hydroxyl radical using dimethyl sulfoxide and deduction of its structure in chloroform. Chem Pharm Bull (Tokyo). 2000 Apr;48(4):467-76. PubMed PMID: 10783063. 14: Imperatore C, Germanò A, d'Avella D, Tomasello F, Costa G. Effects of the radical scavenger AVS on behavioral and BBB changes after experimental subarachnoid hemorrhage. Life Sci. 2000 Jan 21;66(9):779-90. PubMed PMID: 10698353. 15: Hasegawa M, Noda Y, Maeda Y, Yamada K, Nabeshima T. [The 1998 domestic state of development of cognitive enhancers]. Nihon Yakurigaku Zasshi. 1999 Dec;114(6):327-36. Japanese. PubMed PMID: 10672593. 16: Zingarelli B, Scott GS, Hake P, Salzman AL, Szabo C. Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. Shock. 2000 Feb;13(2):126-34. PubMed PMID: 10670842. 17: Hashimoto H, Ohta S, Utsunomiya H, Kumon Y, Sakaki S, Matsuda S, Sakanaka M. Changes in guanylate cyclase activity in arteriolar smooth muscle cells and hemodynamics after ischemia-reperfusion in rats. Acta Neuropathol. 1999 Dec;98(6):603-13. PubMed PMID: 10603036. 18: Komiya T, Higurashi K, Iizuka K, Mizuno Y. A novel free radical scavenger, nicaraven, inhibits human platelet aggregation in vitro. Clin Neuropharmacol. 1999 Jan-Feb;22(1):11-4. PubMed PMID: 10047928. 19: Masaki Y, Kumano K, Endo T, Iwamura M, Koshiba K, Yokota K, Okubo M. Protective effect of nicaraven against prolonged cold kidney preservation and reperfusion injury. Transplant Proc. 1998 Nov;30(7):3758-60. PubMed PMID: 9838646. 20: Yamanaka K, Kumura E, Yoshimine T, Maruno M, Taniguchi M, Kosaka H, Hayakawa T. Cellular expression of inducible nitric oxide synthase following rat cortical incision and its suppression by hydroxyl radical scavenger, 1,2-bis(nicotinamido)propane. Neurosci Res. 1998 Aug;31(4):347-50. PubMed PMID: 9809594.