Seralutinibm, also known as PK-10571 and GB002, is a Novel Inhaled Pdgfr Kinase Inhibitor. Seralutinib demonstrates efficacy in the Su5416 Hypoxia Rat Model of Pulmonary Arterial Hypertension (pah). Localized delivery of GB002 is efficacious on multiple measures of disease activity in the SU5416/H model. GB002 treatment is associated with disease remodeling including improved cardiopulmonary hemodynamics, reduced pulmonary arteriolar muscularization, restoration of BMPR2 signaling, reduced NT-proBNP and improved cytokines.
MedKoo Cat#: 585438
Name: Seralutinib
CAS#: 1619931-27-9
Chemical Formula: C27H27N5O3
Exact Mass: 469.2114
Molecular Weight: 469.55
Elemental Analysis: C, 69.07; H, 5.80; N, 14.92; O, 10.22
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 10.0 | 21.30 | ||
| DMSO | 25.0 | 53.24 | ||
| Ethanol | 10.0 | 21.30 |
The following data is based on the product molecular weight 469.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
