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MedKoo Cat#: 578091 | Name: NEPP-11

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NEPP-11 is a selective JNK signaling pathway inhibitor.

Chemical Structure

NEPP-11
NEPP-11
CAS#313051-12-6

Theoretical Analysis

MedKoo Cat#: 578091

Name: NEPP-11

CAS#: 313051-12-6

Chemical Formula: C26H36O3

Exact Mass: 396.2664

Molecular Weight: 396.57

Elemental Analysis: C, 78.75; H, 9.15; O, 12.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NEPP-11; NEPP-11; NEPP-11
IUPAC/Chemical Name
Methyl 7-((1E,2R)-2-(6-(4-methylphenyl)hexyl)-5-oxocyclopent-3-en-1-ylidene)heptanoate
InChi Key
RHQDOVRJBSRATA-HPTBBYBNSA-N
InChi Code
1S/C26H36O3/c1-21-15-17-22(18-16-21)11-7-3-4-8-12-23-19-20-25(27)24(23)13-9-5-6-10-14-26(28)29-2/h13,15-20,23H,3-12,14H2,1-2H3/b24-13+/t23-/m1/s1
SMILES Code
COC(=O)CCCCC\C=C\1/[C@H](CCCCCCc2ccc(C)cc2)C=CC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 396.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Hirata Y, Furuta K, Miyazaki S, Suzuki M, Kiuchi K. Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells. Brain Res. 2004 Sep 24;1021(2):241-7. doi: 10.1016/j.brainres.2004.06.064. PMID: 15342272. 2. Hirata Y, Furuta K, Suzuki M, Oh-hashi K, Ueno Y, Kiuchi K. Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors in C6 glioma cells. Brain Res. 2012 Oct 30;1482:91-100. doi: 10.1016/j.brainres.2012.09.008. Epub 2012 Sep 12. PMID: 22982731. 3. Furuta K, Maeda M, Hirata Y, Shibata S, Kiuchi K, Suzuki M. Synthesis of neuroprotective cyclopentenone prostaglandin analogs: suppression of manganese-induced apoptosis of PC12 cells. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5487-91. doi: 10.1016/j.bmcl.2006.12.004. Epub 2006 Dec 15. PMID: 17706424. 4. Satoh T, Baba M, Nakatsuka D, Ishikawa Y, Aburatani H, Furuta K, Ishikawa T, Hatanaka H, Suzuki M, Watanabe Y. Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. Eur J Neurosci. 2003 Jun;17(11):2249-55. doi: 10.1046/j.1460-9568.2003.02688.x. PMID: 12814358.