Neptinib | CAS#

MedKoo Cat#: 535116 | Name: Neptinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neptinib is a bioactive chemical.

Chemical Structure

Neptinib

CAS#2085843-51-0

Theoretical Analysis

MedKoo Cat#: 535116

Name: Neptinib

CAS#: 2085843-51-0

Chemical Formula: C22H23ClFN5O2

Exact Mass: 443.1524

Molecular Weight: 443.91

Elemental Analysis: C, 59.53; H, 5.22; Cl, 7.99; F, 4.28; N, 15.78; O, 7.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Neptinib

IUPAC/Chemical Name

2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxy-6-quinazolinyl)-4-(dimethylamino)-, (2E)-

InChi Key

RTAAZCCTCLCXHX-AATRIKPKSA-N

InChi Code

InChI=1S/C22H23ClFN5O2/c1-4-31-20-12-18-15(11-19(20)28-21(30)6-5-9-29(2)3)22(26-13-25-18)27-14-7-8-17(24)16(23)10-14/h5-8,10-13H,4,9H2,1-3H3,(H,28,30)(H,25,26,27)/b6-5+

SMILES Code

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC)/C=C/CN(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 443.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Showalter MR, de Pater I, Lissauer JJ, French RS. The seventh inner moon of Neptune. Nature. 2019 Feb;566(7744):350-353. doi: 10.1038/s41586-019-0909-9. Epub 2019 Feb 20. PMID: 30787452; PMCID: PMC6424524. 2: Verbiscer AJ. A new moon for Neptune. Nature. 2019 Feb;566(7744):328-329. doi: 10.1038/d41586-019-00576-1. PMID: 30787456. 3: Marinier E, Zaheer R, Berry C, Weedmark KA, Domaratzki M, Mabon P, Knox NC, Reimer AR, Graham MR, Chui L, Patterson-Fortin L, Zhang J, Pagotto F, Farber J, Mahony J, Seyer K, Bekal S, Tremblay C, Isaac-Renton J, Prystajecky N, Chen J, Slade P, Van Domselaar G. Neptune: a bioinformatics tool for rapid discovery of genomic variation in bacterial populations. Nucleic Acids Res. 2017 Oct 13;45(18):e159. doi: 10.1093/nar/gkx702. PMID: 29048594; PMCID: PMC5737611. 4: Moses JI, Fletcher LN, Greathouse TK, Orton GS, Hue V. Seasonal Stratospheric Photochemistry on Uranus and Neptune. Icarus. 2018 Jun;307:124-145. doi: 10.1016/j.icarus.2018.02.004. Epub 2018 Feb 10. PMID: 30842687; PMCID: PMC6398965. 5: Drake MJ, Oelke M, Snijder R, Klaver M, Traudtner K, van Charldorp K, Bongaerts D, Van Kerrebroeck P. Incidence of urinary retention during treatment with single tablet combinations of solifenacin+tamsulosin OCAS™ for up to 1 year in adult men with both storage and voiding LUTS: A subanalysis of the NEPTUNE/NEPTUNE II randomized controlled studies. PLoS One. 2017 Feb 6;12(2):e0170726. doi: 10.1371/journal.pone.0170726. PMID: 28166296; PMCID: PMC5293258. 6: Bourrier V, Lovis C, Beust H, Ehrenreich D, Henry GW, Astudillo-Defru N, Allart R, Bonfils X, Ségransan D, Delfosse X, Cegla HM, Wyttenbach A, Heng K, Lavie B, Pepe F. Orbital misalignment of the Neptune-mass exoplanet GJ 436b with the spin of its cool star. Nature. 2018 Jan 25;553(7689):477-480. doi: 10.1038/nature24677. Epub 2017 Dec 18. PMID: 29258300. 7: Barisoni L, Troost JP, Nast C, Bagnasco S, Avila-Casado C, Hodgin J, Palmer M, Rosenberg A, Gasim A, Liensziewski C, Merlino L, Chien HP, Chang A, Meehan SM, Gaut J, Song P, Holzman L, Gibson D, Kretzler M, Gillespie BW, Hewitt SM. Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images. Mod Pathol. 2016 Jul;29(7):671-84. doi: 10.1038/modpathol.2016.58. Epub 2016 Apr 22. PMID: 27102348; PMCID: PMC5515468.

View History

Description:

Chemical Structure

Theoretical Analysis

Price and Availability

Preparing Stock Solutions

View History

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