MedKoo Cat#: 578003 | Name: NBI-35965

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NBI-35965 is a CRF1 receptor antagonist.

Chemical Structure

NBI-35965
NBI-35965
CAS#268546-19-6

Theoretical Analysis

MedKoo Cat#: 578003

Name: NBI-35965

CAS#: 268546-19-6

Chemical Formula: C21H22Cl2N4

Exact Mass: 400.1222

Molecular Weight: 401.33

Elemental Analysis: C, 62.85; H, 5.53; Cl, 17.67; N, 13.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NBI-35965; NBI 35965; NBI35965
IUPAC/Chemical Name
6H-1,3,6,8a-Tetraazaacenaphthylene, 6-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-, (7S)-
InChi Key
SUCZRVASFXLXDM-HNNXBMFYSA-N
InChi Code
1S/C21H22Cl2N4/c1-3-15-11-27-21-18(26(15)10-13-4-5-13)8-12(2)24-20(21)19(25-27)16-7-6-14(22)9-17(16)23/h6-9,13,15H,3-5,10-11H2,1-2H3/t15-/m0/s1
SMILES Code
CC[C@H]1Cn2nc(c3ccc(Cl)cc3Cl)c4nc(C)cc(N1CC5CC5)c24
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Li C, McCloskey N, Phillips J, Simmons SJ, Kirby LG. CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement. Psychopharmacology (Berl). 2021 Jan;238(1):29-40. doi: 10.1007/s00213-020-05652-3. Epub 2020 Nov 24. PMID: 33231727; PMCID: PMC7796902. 2. Million M, Grigoriadis DE, Sullivan S, Crowe PD, McRoberts JA, Zhou H, Saunders PR, Maillot C, Mayer EA, Taché Y. A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 2003 Sep 19;985(1):32-42. doi: 10.1016/s0006-8993(03)03027-0. PMID: 12957366. 3. Kosoyan HP, Grigoriadis DE, Taché Y. The CRF(1) receptor antagonist, NBI-35965, abolished the activation of locus coeruleus neurons induced by colorectal distension and intracisternal CRF in rats. Brain Res. 2005 Sep 14;1056(1):85-96. doi: 10.1016/j.brainres.2005.07.010. PMID: 16095571.