Synonym
Luciculine; Napelline
IUPAC/Chemical Name
(3R,6S,6aR,6bR,8S,9R,11R,11aR,12R,12aR,14R)-1-ethyl-3-methyl-10-methylenetetradecahydro-3,6a,12-(epiethane[1,1,2]triyl)-9,11a-methanoazuleno[2,1-b]azocine-6,8,11-triol
InChi Key
AZAZKLKDEOMJBJ-AFJRDBIPSA-N
InChi Code
InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3/t12-,13+,14+,15-,16-,17+,18-,19-,20+,21+,22+/m1/s1
SMILES Code
CCN1C[C@]2(C)CC[C@H](O)[C@@]34[C@@H]2C[C@@H]([C@@H]13)[C@@]56C[C@@H]([C@@H](O)C[C@@H]45)C(=C)[C@H]6O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
359.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Demirbağ Karaali M, Aydın Karataş E. Investigation of the potential anticancer effects of napelline and talatisamine dirterpenes on experimental brain tumor models. Cytotechnology. 2020 Aug;72(4):569-578. doi: 10.1007/s10616-020-00405-8. Epub 2020 Jun 11. PMID: 32529352; PMCID: PMC7450011.
2. Zyuz'kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Losev EA, Simanina EV, Chaikovskiy AV, Suslov NI, Povet'eva TN, Krapivin AV, Nesterova YV, Agafonov VI, Minakova MY, Stavrova LA, Danilets MG, Ligacheva AA, Trofimova ES, Ivanova AN, Goldberg VE, Reikchart DV, Dygai AM. Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression. Bull Exp Biol Med. 2013 Aug;155(4):439-42. doi: 10.1007/s10517-013-2172-7. PMID: 24143362.
