Synonym
ONO-4057; ONO4057; ONO 4057; Ono-LB-457; Ono LB 457; OnoLB457; Ono-LB 457
IUPAC/Chemical Name
(E)-5-(2-(2-carboxyethyl)-3-((6-(4-methoxyphenyl)hex-5-en-1-yl)oxy)phenoxy)pentanoic acid
InChi Key
JOPSSWGWLCLPPF-RUDMXATFSA-N
InChi Code
InChI=1S/C27H34O7/c1-32-22-15-13-21(14-16-22)9-4-2-3-6-19-33-24-10-8-11-25(23(24)17-18-27(30)31)34-20-7-5-12-26(28)29/h4,8-11,13-16H,2-3,5-7,12,17-20H2,1H3,(H,28,29)(H,30,31)/b9-4+
SMILES Code
O=C(O)CCC1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC=C1OCCCCC(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
470.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Takeichi T, Uemoto S, Minamiguchi S, Takeyoshi I, Inomata Y, Tanaka K, Kobayashi E. Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver. World J Gastroenterol. 2009 Dec 7;15(45):5712-5. PubMed PMID: 19960569; PubMed Central PMCID: PMC2789225.
2: Kawasaki Y, Tanji M, Takano K, Fukuda Y, Isome M, Nozawa R, Suzuki H, Hosoya M. The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis. Nephrol Dial Transplant. 2005 Dec;20(12):2697-703. Epub 2005 Oct 12. PubMed PMID: 16221713.
3: Suzuki S, Kuroda T, Kazama JI, Imai N, Kimura H, Arakawa M, Gejyo F. The leukotriene B4 receptor antagonist ONO-4057 inhibits nephrotoxic serum nephritis in WKY rats. J Am Soc Nephrol. 1999 Feb;10(2):264-70. PubMed PMID: 10215325.
4: Kishikawa K, Nakao S, Matsumoto S, Kondo K, Hamanaka N. Estimation of antagonistic activity of ONO-4057 against leukotriene B4 in humans. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:279-81. PubMed PMID: 7732853.
5: Kishikawa K, Tateishi N, Maruyama T, Seo R, Toda M, Miyamoto T. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. PubMed PMID: 1332129.
