Synonym
AA29504; AA 29504; AA-29504;
IUPAC/Chemical Name
ethyl (2-amino-4-((2,4,6-trimethylbenzyl)amino)phenyl)carbamate
InChi Key
SCOOTUMXCXKEAD-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H25N3O2/c1-5-24-19(23)22-18-7-6-15(10-17(18)20)21-11-16-13(3)8-12(2)9-14(16)4/h6-10,21H,5,11,20H2,1-4H3,(H,22,23)
SMILES Code
O=C(OCC)NC1=CC=C(NCC2=C(C)C=C(C)C=C2C)C=C1N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
327.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sikstus S, Benkherouf AY, Soini SL, Uusi-Oukari M. The Influence of AA29504 on GABAA Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity. Neurochem Res. 2022 Mar;47(3):667-678. doi: 10.1007/s11064-021-03475-y. Epub 2021 Nov 2. PMID: 34727270; PMCID: PMC8847198.
2: McGrath M, Tolia M, Raines DE. The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents. Pharmacol Rep. 2020 Feb;72(1):260-266. doi: 10.1007/s43440-019-00031-y. Epub 2020 Jan 8. PMID: 32016849; PMCID: PMC7006677.
3: Olander ER, Madjroh N, Bunch L, Söderhielm PC, Jensen AA. Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem Pharmacol. 2018 Apr;150:305-319. doi: 10.1016/j.bcp.2018.02.015. Epub 2018 Feb 16. PMID: 29454619.
4: Falk-Petersen CB, Søgaard R, Madsen KL, Klein AB, Frølund B, Wellendorph P. Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes. Basic Clin Pharmacol Toxicol. 2017 Aug;121(2):119-129. doi: 10.1111/bcpt.12778. Epub 2017 May 25. PMID: 28299900.
5: Vardya I, Hoestgaard-Jensen K, Nieto-Gonzalez JL, Dósa Z, Boddum K, Holm MM, Wolinsky TD, Jones KA, Dalby NO, Ebert B, Jensen K. Positive modulation of δ-subunit containing GABA(A) receptors in mouse neurons. Neuropharmacology. 2012 Sep;63(3):469-79. doi: 10.1016/j.neuropharm.2012.04.023. Epub 2012 Apr 30. PMID: 22579928.
6: Hoestgaard-Jensen K, Dalby NO, Wolinsky TD, Murphey C, Jones KA, Rottländer M, Frederiksen K, Watson WP, Jensen K, Ebert B. Pharmacological characterization of a novel positive modulator at alpha 4 beta 3 delta-containing extrasynaptic GABA(A) receptors. Neuropharmacology. 2010 Mar-Apr;58(4-5):702-11. doi: 10.1016/j.neuropharm.2009.12.023. Epub 2010 Jan 12. PMID: 20060846.
