BMS-223131 | CAS# 275375-69-4 | maxi-K channels opener

MedKoo Cat#: 577820 | Name: BMS-223131

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-223131 is a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels. BMS-223131 effectively reduced stress-induced colonic motility and visceral nociception supporting the potential utility of maxi-K channel openers for the treatment of bowel disorders involving dysfunctional motility and visceral sensitivity.

Chemical Structure

BMS-223131

CAS#275375-69-4

Theoretical Analysis

MedKoo Cat#: 577820

Name: BMS-223131

CAS#: 275375-69-4

Chemical Formula: C18H13ClF3NO3

Exact Mass: 383.0536

Molecular Weight: 383.75

Elemental Analysis: C, 56.34; H, 3.41; Cl, 9.24; F, 14.85; N, 3.65; O, 12.51

Price and Availability

Size	Price	Availability
1mg	USD 150.00	Ready to ship
5mg	USD 450.00	Ready to ship
10mg	USD 750.00	Ready to ship
25mg	USD 1,250.00	Ready to ship
50mg	USD 2,050.00	Ready to ship
100mg	USD 3,450.00	Ready to ship

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Related CAS #

No Data

Synonym

BMS-223131; BMS 223131; BMS223131

IUPAC/Chemical Name

4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one

InChi Key

QESHSZWKJULSAR-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H13ClF3NO3/c19-10-2-4-15(25)13(8-10)16-11(5-6-24)17(26)23-14-3-1-9(7-12(14)16)18(20,21)22/h1-4,7-8,24-25H,5-6H2,(H,23,26)

SMILES Code

C1=CC2=C(C=C1C(F)(F)F)C(=C(C(=O)N2)CCO)C3=C(C=CC(=C3)Cl)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#Y23X03M20

QC Data

View QC data: current batch, Lot#Y23X03M20

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

BMS-223131 is a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels.

In vitro activity:

TBD

In vivo activity:

BMS-223131 (2, 6, or 20 mg/kg i.p.) produced a small but dose-dependent and significant reduction in cumulative 24-h fecal output. Fecal output in response to stress (1-h restraint plus bursts of air to the face) was markedly inhibited by BMS-223131, and moisture content was significantly reduced. With regard to visceral pain, the transient and distention-dependent reduction in arterial pressure in anesthetized animals was inhibited by BMS-223131 in a dose-dependent manner. Distension-induced abdominal withdrawal in conscious rats was also dose-dependently attenuated by BMS-223131. Reference: J Pharmacol Exp Ther. 2005 May;313(2):840-7. https://pubmed.ncbi.nlm.nih.gov/15701710/

Preparing Stock Solutions

The following data is based on the product molecular weight 383.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Sivarao DV, Newberry K, Langdon S, Lee AV, Hewawasam P, Plym MJ, Signor L, Myers R, Lodge NJ. Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. J Pharmacol Exp Ther. 2005 May;313(2):840-7. doi: 10.1124/jpet.104.079285. Epub 2005 Feb 8. Erratum in: J Pharmacol Exp Ther. 2005 Oct;315(1):476. PMID: 15701710.

In vitro protocol:

TBD

In vivo protocol:

1. Sivarao DV, Newberry K, Langdon S, Lee AV, Hewawasam P, Plym MJ, Signor L, Myers R, Lodge NJ. Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. J Pharmacol Exp Ther. 2005 May;313(2):840-7. doi: 10.1124/jpet.104.079285. Epub 2005 Feb 8. Erratum in: J Pharmacol Exp Ther. 2005 Oct;315(1):476. PMID: 15701710.