MedKoo Cat#: 465954 | Name: Posovolone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Posovolone, also known as Co 134444, is a GABAA receptor positive allosteric modulator. It is also an antidepressant. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.

Chemical Structure

Posovolone
Posovolone
CAS#256955-84-7 (free base)

Theoretical Analysis

MedKoo Cat#: 465954

Name: Posovolone

CAS#: 256955-84-7 (free base)

Chemical Formula: C26H40N2O3

Exact Mass: 428.3039

Molecular Weight: 428.62

Elemental Analysis: C, 72.86; H, 9.41; N, 6.54; O, 11.20

Price and Availability

Size Price Availability Quantity
25mg USD 750.00 2 Weeks
50mg USD 1,250.00 2 Weeks
100mg USD 1,950.00 2 Weeks
200mg USD 2,950.00 2 Weeks
500mg USD 4,250.00 2 Weeks
1g USD 5,950.00 2 Weeks
2g USD 8,950.00 2 Weeks
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Synonym
Posovolone; CO-134444; CO 134444; CO134444;
IUPAC/Chemical Name
1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3-(methoxymethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(1H-imidazol-1-yl)ethan-1-one
InChi Key
BRVGKZNQWCQKTC-MVCIVNJCSA-N
InChi Code
InChI=1S/C26H40N2O3/c1-24-10-11-26(30,16-31-3)14-18(24)4-5-19-20-6-7-22(25(20,2)9-8-21(19)24)23(29)15-28-13-12-27-17-28/h12-13,17-22,30H,4-11,14-16H2,1-3H3/t18-,19-,20-,21-,22+,24-,25-,26+/m0/s1
SMILES Code
C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(CN5C=CN=C5)=O)([H])C[C@](COC)(O)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Vanover KE, Hogenkamp DJ, Lan NC, Gee KW, Carter RB. Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology (Berl). 2001 May;155(3):285-91. doi: 10.1007/s002130100695. PMID: 11432691.