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MedKoo Cat#: 591179 | Name: Melamine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Melamine is widely used in production of certain plastics.

Chemical Structure

Melamine
Melamine
CAS#108-78-1

Theoretical Analysis

MedKoo Cat#: 591179

Name: Melamine

CAS#: 108-78-1

Chemical Formula: C3H6N6

Exact Mass: 126.0654

Molecular Weight: 126.12

Elemental Analysis: C, 28.57; H, 4.80; N, 66.63

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 Weeks
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Related CAS #
No Data
Synonym
Melamine; NSC 2130; NSC-2130; NSC2130
IUPAC/Chemical Name
1,3,5-Triazine-2,4,6-triamine
InChi Key
JDSHMPZPIAZGSV-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6,4,5,6,7,8,9)
SMILES Code
NC1=NC(N)=NC(N)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials.
In vitro activity:
To explore the physiological relevance of such melamine-augmented calcium crystal formation, this study used 2-dimensional (2D) and 3D microfluidic (MF) device, embedded with PT cells, which also resembled the effect of melamine-stimulated CaP, CaOx and mixed crystal formation. Significantly, addition of preformed CaP and/or CaOx crystal in the presence of melamine, further potentiated those crystal formations in 3D MFs, which helped the growth and aggregation of mixed crystals. Reference: Sci Rep. 2019 Jan 29;9(1):875. https://pubmed.ncbi.nlm.nih.gov/30696888/
In vivo activity:
Prenatal melamine exposure (PME) was given by oral treatment to pregnant female rats through the whole gestational days with 400mg/day/kg bodyweight. The results of behavioral test showed that PME lead serious deficits of memory and re-acquisition abilities. PME depressed depotentiation in the hippocampal CA1 area of the PME group, but no alteration in LTP. Reference: Neurotoxicology. 2017 Sep;62:56-63. https://pubmed.ncbi.nlm.nih.gov/28529052/
Solvent mg/mL mM
Solubility
DMSO 12.5 99.11
Water 1.0 7.93
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 126.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Gombedza F, Evans S, Shin S, Awuah Boadi E, Zhang Q, Nie Z, Bandyopadhyay BC. Melamine promotes calcium crystal formation in three-dimensional microfluidic device. Sci Rep. 2019 Jan 29;9(1):875. doi: 10.1038/s41598-018-37191-5. PMID: 30696888; PMCID: PMC6351636. 2. Alam MF, Laskar AA, Ahmed S, Shaida MA, Younus H. Colorimetric method for the detection of melamine using in-situ formed silver nanoparticles via tannic acid. Spectrochim Acta A Mol Biomol Spectrosc. 2017 Aug 5;183:17-22. doi: 10.1016/j.saa.2017.04.021. Epub 2017 Apr 17. PMID: 28432916. 3. An L, Sun W. Prenatal melamine exposure induces impairments of spatial cognition and hippocampal synaptic plasticity in female adolescent rats. Neurotoxicology. 2017 Sep;62:56-63. doi: 10.1016/j.neuro.2017.05.008. Epub 2017 May 18. PMID: 28529052. 4. Kyoya T, Hori M, Terada M. Evaluation of the in vivo mutagenicity of melamine by the RBC Pig-a assay and PIGRET assay. Mutat Res Genet Toxicol Environ Mutagen. 2016 Nov 15;811:43-48. doi: 10.1016/j.mrgentox.2016.04.003. Epub 2016 May 10. PMID: 27931813.
In vitro protocol:
1. Gombedza F, Evans S, Shin S, Awuah Boadi E, Zhang Q, Nie Z, Bandyopadhyay BC. Melamine promotes calcium crystal formation in three-dimensional microfluidic device. Sci Rep. 2019 Jan 29;9(1):875. doi: 10.1038/s41598-018-37191-5. PMID: 30696888; PMCID: PMC6351636. 2. Alam MF, Laskar AA, Ahmed S, Shaida MA, Younus H. Colorimetric method for the detection of melamine using in-situ formed silver nanoparticles via tannic acid. Spectrochim Acta A Mol Biomol Spectrosc. 2017 Aug 5;183:17-22. doi: 10.1016/j.saa.2017.04.021. Epub 2017 Apr 17. PMID: 28432916.
In vivo protocol:
1. An L, Sun W. Prenatal melamine exposure induces impairments of spatial cognition and hippocampal synaptic plasticity in female adolescent rats. Neurotoxicology. 2017 Sep;62:56-63. doi: 10.1016/j.neuro.2017.05.008. Epub 2017 May 18. PMID: 28529052. 2. Kyoya T, Hori M, Terada M. Evaluation of the in vivo mutagenicity of melamine by the RBC Pig-a assay and PIGRET assay. Mutat Res Genet Toxicol Environ Mutagen. 2016 Nov 15;811:43-48. doi: 10.1016/j.mrgentox.2016.04.003. Epub 2016 May 10. PMID: 27931813.
1: Call E, Bill B, McLean C, Call N, Bernkopf A, Oberg C. Hazardous Drug Contamination of Drug Preparation Devices and Staff: A Contamination Study Simulating the Use of Chemotherapy Drugs in a Clinical Setting. Hosp Pharm. 2017 Sep;52(8):551-558. doi: 10.1177/0018578717722870. Epub 2017 Aug 20. PubMed PMID: 29276288; PubMed Central PMCID: PMC5735723. 2: Li WC, Chow CF. Adverse child health impacts resulting from food adulterations in the Greater China Region. J Sci Food Agric. 2017 Sep;97(12):3897-3916. doi: 10.1002/jsfa.8405. Epub 2017 Jun 27. Review. PubMed PMID: 28466508. 3: Mundt KA, Gallagher AE, Dell LD, Natelson EA, Boffetta P, Gentry PR. Does occupational exposure to formaldehyde cause hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells? Crit Rev Toxicol. 2017 Aug;47(7):592-602. doi: 10.1080/10408444.2017.1301878. Epub 2017 May 2. Review. PubMed PMID: 28462599. 4: Zheng Y, Yu Z, Lin F, Guo F, Alamry KA, Taib LA, Asiri AM, Wang X. Sulfur-Doped Carbon Nitride Polymers for Photocatalytic Degradation of Organic Pollutant and Reduction of Cr(VI). Molecules. 2017 Apr 1;22(4). pii: E572. doi: 10.3390/molecules22040572. PubMed PMID: 28368315. 5: Anand K, Singh T, Madhumitha G, Phulukdaree A, Gengan RM, Chuturgoon AA. Biosynthesis and computational analysis of amine-ended dual thiol ligand functionalized gold nanoparticles for conventional spectroscopy detection of melamine. J Photochem Photobiol B. 2017 Apr;169:75-82. doi: 10.1016/j.jphotobiol.2017.02.019. Epub 2017 Feb 24. PubMed PMID: 28288401. 6: Kyoya T, Hori M, Terada M. Evaluation of the in vivo mutagenicity of melamine by the RBC Pig-a assay and PIGRET assay. Mutat Res. 2016 Nov 15;811:43-48. doi: 10.1016/j.mrgentox.2016.04.003. Epub 2016 May 10. PubMed PMID: 27931813. 7: Wen JG, Liu XJ, Wang ZM, Li TF, Wahlqvist ML. Melamine-contaminated milk formula and its impact on children. Asia Pac J Clin Nutr. 2016 Dec;25(4):697-705. doi: 10.6133/apjcn.072016.01. Review. PubMed PMID: 27702712. 8: Ge K, Zhang C, Sun W, Liu H, Jin Y, Li Z, Liang XJ, Jia G, Zhang J. Up-Conversion Y2O3:Yb(3+),Er(3+) Hollow Spherical Drug Carrier with Improved Degradability for Cancer Treatment. ACS Appl Mater Interfaces. 2016 Sep 28;8(38):25078-86. doi: 10.1021/acsami.6b07215. Epub 2016 Sep 14. PubMed PMID: 27589262. 9: Li J, Zhang Y, Kuang X, Wang Z, Wei Q. A network signal amplification strategy of ultrasensitive photoelectrochemical immunosensing carcinoembryonic antigen based on CdSe/melamine network as label. Biosens Bioelectron. 2016 Nov 15;85:764-770. doi: 10.1016/j.bios.2016.05.088. Epub 2016 May 31. PubMed PMID: 27281106. 10: Rong M, Cai Z, Xie L, Lin C, Song X, Luo F, Wang Y, Chen X. Study on the Ultrahigh Quantum Yield of Fluorescent P,O-g-C3 N4 Nanodots and its Application in Cell Imaging. Chemistry. 2016 Jun 27;22(27):9387-95. doi: 10.1002/chem.201601065. Epub 2016 Jun 1. PubMed PMID: 27249019. 11: List M, Puchinger H, Gabriel H, Monkowius U, Schwarzinger C. N-Methylmelamines: Synthesis, Characterization, and Physical Properties. J Org Chem. 2016 May 20;81(10):4066-75. doi: 10.1021/acs.joc.6b00355. Epub 2016 May 5. PubMed PMID: 27100712. 12: Fu J, Wang H, Gao J, Yu M, Wang R, Yang Z, Zhang T. Rapamycin Effectively Impedes Melamine-Induced Impairments of Cognition and Synaptic Plasticity in Wistar Rats. Mol Neurobiol. 2017 Mar;54(2):819-832. doi: 10.1007/s12035-016-9687-7. Epub 2016 Jan 15. PubMed PMID: 26768596. 13: Weidemann DK, Weaver VM, Fadrowski JJ. Toxic environmental exposures and kidney health in children. Pediatr Nephrol. 2016 Nov;31(11):2043-54. doi: 10.1007/s00467-015-3222-3. Epub 2015 Oct 12. Review. PubMed PMID: 26458883; PubMed Central PMCID: PMC4829489. 14: Toyoda T, Cho YM, Akagi J, Mizuta Y, Hirata T, Nishikawa A, Ogawa K. Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX. Toxicol Sci. 2015 Dec;148(2):400-8. doi: 10.1093/toxsci/kfv192. Epub 2015 Sep 3. PubMed PMID: 26338220. 15: Danciu C, Berkó S, Varju G, Balázs B, Kemény L, Németh IB, Cioca A, Petruș A, Dehelean C, Cosmin CI, Amaricai E, Toma CC. The Effect of Electroporation of a Lyotroic Liquid Crystal Genistein-Based Formulation in the Recovery of Murine Melanoma Lesions. Int J Mol Sci. 2015 Jul 8;16(7):15425-41. doi: 10.3390/ijms160715425. PubMed PMID: 26184156; PubMed Central PMCID: PMC4519906. 16: Qiao X, Zhang L, Zhang N, Wang X, Qin X, Yan H, Liu H. Imidazolium embedded C8 based stationary phase for simultaneous reversed-phase/hydrophilic interaction mixed-mode chromatography. J Chromatogr A. 2015 Jun 26;1400:107-16. doi: 10.1016/j.chroma.2015.04.060. Epub 2015 May 6. PubMed PMID: 25981287. 17: Duan X, Dai XX, Wang T, Liu HL, Sun SC. Melamine negatively affects oocyte architecture, oocyte development and fertility in mice. Hum Reprod. 2015 Jul;30(7):1643-52. doi: 10.1093/humrep/dev091. Epub 2015 Apr 29. PubMed PMID: 25924656. 18: Huang J, Chen F, Zhang Q, Zhan Y, Ma D, Xu K, Zhao Y. 3D silver nanoparticles decorated zinc oxide/silicon heterostructured nanomace arrays as high-performance surface-enhanced Raman scattering substrates. ACS Appl Mater Interfaces. 2015 Mar 18;7(10):5725-35. doi: 10.1021/am507857x. Epub 2015 Mar 9. PubMed PMID: 25731067. 19: Wang H, Gao N, Li Z, Yang Z, Zhang T. Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level. Mol Neurobiol. 2016 Apr;53(3):1718-1729. doi: 10.1007/s12035-014-9073-2. Epub 2015 Mar 1. PubMed PMID: 25724280. 20: Komeda M, Furukawa C. [Skin care during non-invasive positive pressure ventilation in nursing home residents]. Gan To Kagaku Ryoho. 2014 Dec;41 Suppl 1:72-4. Japanese. PubMed PMID: 25595089.

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