LC28 | CAS#723746-47-2 | STAT3 signaling inhibitor

MedKoo Cat#: 465928 | Name: LC28

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LC28 is a novel inhibitor of STAT3 signaling, suppressing survival of cisplatin-resistant ovarian cancer cells.

Chemical Structure

LC28

CAS#723746-47-2

Theoretical Analysis

MedKoo Cat#: 465928

Name: LC28

CAS#: 723746-47-2

Chemical Formula: C17H13BrClNO2

Exact Mass: 376.9818

Molecular Weight: 378.65

Elemental Analysis: C, 53.92; H, 3.46; Br, 21.10; Cl, 9.36; N, 3.70; O, 8.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LC28; LC 28; LC-28;

IUPAC/Chemical Name

(E)-4-bromo-2-(3-(4-chlorophenyl)acryloyl)-7-(methylamino)cyclohepta-2,4,6-trien-1-one

InChi Key

BUMNZRXLKXQECY-RUDMXATFSA-N

InChi Code

InChI=1S/C17H13BrClNO2/c1-20-15-8-5-12(18)10-14(17(15)22)16(21)9-4-11-2-6-13(19)7-3-11/h2-10H,1H3,(H,20,22)/b9-4+

SMILES Code

O=C1C(C(/C=C/C2=CC=C(Cl)C=C2)=O)=CC(Br)=CC=C1NC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 378.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang W, Liu Y, Wang J, Yuan X, Jin HW, Zhang LR, Zhang JT, Liu ZM, Cui JR. Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. Eur J Med Chem. 2018 Sep 5;157:887-897. doi: 10.1016/j.ejmech.2018.08.037. Epub 2018 Aug 14. PMID: 30145375.