LB 11058 is a novel parenteral cephalosporin with a C-3 pyrimidinyl-substituted vinyl sulfide group and a C-7 2-amino-5-chloro-1,3-thiazole group. LB 11058 is very active against Streptococcus pneumoniae. LB 11058 was also very active against both beta-hemolytic streptococci. LB 11058 has a susceptibility pattern similar to that of S. aureus, with all isolates being inhibited at </=1 micro g/ml. LB 11058 also showed reasonable in vitro activity against Enterococcus faecalis, including vancomycin-resistant strains (MIC(50), 1 micro g/ml), and Bacillus spp. (MIC(50), 0.25 micro g/ml).
MedKoo Cat#: 145138
Name: LB 11058
CAS#: 591207-81-7
Chemical Formula: C18H15ClN8O6S3
Exact Mass: 569.9965
Molecular Weight: 571.00
Elemental Analysis: C, 37.86; H, 2.65; Cl, 6.21; N, 19.62; O, 16.81; S, 16.84
The following data is based on the product molecular weight 571.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
