LK 157 | CAS#209536-74-3 | tricyclic carbapenem

MedKoo Cat#: 599058 | Name: LK 157

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases.

Chemical Structure

LK 157

CAS#209536-74-3

Theoretical Analysis

MedKoo Cat#: 599058

Name: LK 157

CAS#: 209536-74-3

Chemical Formula: C14H17NO4

Exact Mass: 263.1158

Molecular Weight: 263.29

Elemental Analysis: C, 63.87; H, 6.51; N, 5.32; O, 24.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LK 157; LK-157; LK157

IUPAC/Chemical Name

(5S,8aS,8bR,E)-1-ethylidene-5-methoxy-2-oxo-1,2,5,6,7,8,8a,8b-octahydroazeto[2,1-a]isoindole-4-carboxylic acid

InChi Key

ACQFJWSLWQLLIA-PLWQYUFKSA-N

InChi Code

InChI=1S/C14H17NO4/c1-3-7-11-8-5-4-6-9(19-2)10(8)12(14(17)18)15(11)13(7)16/h3,8-9,11H,4-6H2,1-2H3,(H,17,18)/b7-3+/t8-,9-,11-/m0/s1

SMILES Code

C/C=C1[C@H]2[C@H]3CCC[C@H](OC)C3=C(C(O)=O)N2C\1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 263.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Paukner S, Hesse L, Prezelj A, Solmajer T, Urleb U. In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor. Antimicrob Agents Chemother. 2009 Feb;53(2):505-11. doi: 10.1128/AAC.00085-08. Epub 2008 Dec 15. PubMed PMID: 19075067; PubMed Central PMCID: PMC2630636. 2: Iglicar P, Legen I, Vilfan G, Selic L, Prezelj A. Permeability of a novel beta-lactamase inhibitor LK-157 and its ester prodrugs across rat jejunum in vitro. J Pharm Pharmacol. 2009 Sep;61(9):1211-8. doi: 10.1211/jpp/61.09.0011. PubMed PMID: 19703371. 3: Swathi CH, Chikala R, Ratnakar KS, Sritharan V. A structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs). Indian J Med Res. 2016 Jul;144(1):21-31. doi: 10.4103/0971-5916.193279. Review. PubMed PMID: 27834322; PubMed Central PMCID: PMC5116894. 4: Fernea A, Galleni M, Frère JM. Kinetics of the Interaction between BAL29880 and LK157 and the Class C β-Lactamase CHE-1. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1747-50. doi: 10.1128/AAC.02062-15. PubMed PMID: 26729500; PubMed Central PMCID: PMC4775998.