Synonym
TASP0434299; TASP 0434299; TASP-0434299;
IUPAC/Chemical Name
N-(tert-butyl)-2-(2-(3-methoxyphenyl)-6-(3-morpholinopropoxy)-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)acetamide
InChi Key
XVASOLQWDBYKQE-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H35N5O5/c1-27(2,3)30-23(33)18-32-25(19-7-5-8-20(15-19)35-4)29-24-22(26(32)34)16-21(17-28-24)37-12-6-9-31-10-13-36-14-11-31/h5,7-8,15-17H,6,9-14,18H2,1-4H3,(H,30,33)
SMILES Code
O=C(NC(C)(C)C)CN(C(C1=CC=CC(OC)=C1)=NC2=NC=C(OCCCN3CCOCC3)C=C24)C4=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
509.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Koga K, Nagai Y, Hanyu M, Yoshinaga M, Chaki S, Ohtake N, Ozaki S, Zhang MR, Suhara T, Higuchi M. High-Contrast PET Imaging of Vasopressin V1B Receptors with a Novel Radioligand, 11C-TASP699. J Nucl Med. 2017 Oct;58(10):1652-1658. doi: 10.2967/jnumed.116.188698. Epub 2017 Apr 27. PMID: 28450560.
2: Koga K, Yoshinaga M, Uematsu Y, Nagai Y, Miyakoshi N, Shimoda Y, Fujinaga M, Minamimoto T, Zhang MR, Higuchi M, Ohtake N, Suhara T, Chaki S. TASP0434299: A Novel Pyridopyrimidin-4-One Derivative as a Radioligand for Vasopressin V1B Receptor. J Pharmacol Exp Ther. 2016 Jun;357(3):495-508. doi: 10.1124/jpet.116.232942. Epub 2016 Mar 30. PMID: 27029585.
