MedKoo Cat#: 562242 | Name: TASIN-1 Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TASIN-1 Hydrochloride is a truncated APC selective inhibitor. It acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

Chemical Structure

TASIN-1 Hydrochloride
TASIN-1 Hydrochloride
CAS#1678515-13-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 562242

Name: TASIN-1 Hydrochloride

CAS#: 1678515-13-3 (HCl)

Chemical Formula: C18H29ClN2O3S

Exact Mass:

Molecular Weight: 388.95

Elemental Analysis: C, 55.58; H, 7.52; Cl, 9.11; N, 7.20; O, 12.34; S, 8.24

Price and Availability

Size Price Availability Quantity
5mg USD 400.00
25mg USD 800.00
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Synonym
TASIN-1 Hydrochloride; TASIN 1 Hydrochloride; TASIN1 Hydrochloride; TASIN-1 HCl; TASIN 1 HCl; TASIN1 HCl; Truncated APC Selective INhibitor-1;
IUPAC/Chemical Name
1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine hydrochloride
InChi Key
TXDTUQPRRXNCLP-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18;/h3-6,15-16H,7-14H2,1-2H3;1H
SMILES Code
CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 Feb 21. pii: molcanther.0887.2017. doi: 10.1158/1535-7163.MCT-17-0887. [Epub ahead of print] PubMed PMID: 29467273. 2: Cully M. Anticancer drugs: Exploiting a weakness in colorectal cancers. Nat Rev Drug Discov. 2016 Nov 29;15(12):820-821. doi: 10.1038/nrd.2016.247. PubMed PMID: 27895333. 3: Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140. PubMed PMID: 27798265.