SJ10542 | CAS#2789678-92-6 | JAK2/3 PROTAC

MedKoo Cat#: 465891 | Name: SJ10542

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SJ10542 is JAK2/3 PROTAC. SJ10542 displayed high selectivity over GSPT1 and other members of the JAK family and potency in patient-derived ALL cells containing both JAK2 fusions and CRLF2 rearrangements.

Chemical Structure

SJ10542

CAS#2789678-92-6

Theoretical Analysis

MedKoo Cat#: 465891

Name: SJ10542

CAS#: 2789678-92-6

Chemical Formula: C41H46N12O5S

Exact Mass: 818.3435

Molecular Weight: 818.96

Elemental Analysis: C, 60.13; H, 5.66; N, 20.52; O, 9.77; S, 3.91

Price and Availability

Size	Price	Availability	Quantity
2mg	USD 750.00	2 Weeks

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Related CAS #

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Synonym

SJ10542; SJ 10542; SJ-10542;

IUPAC/Chemical Name

4-((4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide

InChi Key

WBEBZVDAHMXWJN-UHFFFAOYSA-N

InChi Code

InChI=1S/C41H46N12O5S/c1-2-59(57,58)52-26-41(27-52,15-16-42)53-25-30(24-45-53)36-34-14-18-43-37(34)49-40(48-36)46-31-8-4-29(5-9-31)38(55)44-17-3-19-50-20-22-51(23-21-50)32-10-6-28(7-11-32)33-12-13-35(54)47-39(33)56/h4-11,14,18,24-25,33H,2-3,12-13,15,17,19-23,26-27H2,1H3,(H,44,55)(H,47,54,56)(H2,43,46,48,49)

SMILES Code

O=C(NCCCN1CCN(C2=CC=C(C(CC3)C(NC3=O)=O)C=C2)CC1)C4=CC=C(NC5=NC(C6=CN(C7(CC#N)CN(S(=O)(CC)=O)C7)N=C6)=C8C(NC=C8)=N5)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 818.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Alcock LJ, Chang Y, Jarusiewicz JA, Actis M, Nithianantham S, Mayasundari A, Min J, Maxwell D, Hunt J, Smart B, Yang JJ, Nishiguchi G, Fischer M, Mullighan CG, Rankovic Z. Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. ACS Med Chem Lett. 2022 Feb 21;13(3):475-482. doi: 10.1021/acsmedchemlett.1c00650. PMID: 35300081; PMCID: PMC8919382.