SJ-106C is a potent mitochondria-targeted SIRT3 inhibitor. SJ-106C, achieved by using a triethylammonium group, which helps to increase both solubility and SIRT3 inhibition potency. SJ-106C, while still inhibiting SIRT1 and SIRT2, is enriched in the mitochondria to help with SIRT3 inhibition. It is more active against DLBCL than other solid tumor cells and effectively inhibits DLBCL xenograft tumor growth.
MedKoo Cat#: 127745
Name: SJ-106C
CAS#: N/A
Chemical Formula: C38H69ClN4O3S
Exact Mass: 696.4779
Molecular Weight: 697.51
Elemental Analysis: C, 65.44; H, 9.97; Cl, 5.08; N, 8.03; O, 6.88; S, 4.60
The following data is based on the product molecular weight 697.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
