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MedKoo Cat#: 555383 | Name: PF-4211

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-4211 is a potent D1 receptor agonist.

Chemical Structure

PF-4211
PF-4211
CAS#2292115-41-2

Theoretical Analysis

MedKoo Cat#: 555383

Name: PF-4211

CAS#: 2292115-41-2

Chemical Formula: C17H13N3O2

Exact Mass: 291.1008

Molecular Weight: 291.31

Elemental Analysis: C, 70.09; H, 4.50; N, 14.42; O, 10.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF-4211; PF 4211; PF4211;
IUPAC/Chemical Name
4-(4-(1-methyl-1H-pyrazol-5-yl)phenoxy)furo[3,2-c]pyridine
InChi Key
ZYVVTSUQLCQHJC-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13N3O2/c1-20-15(6-10-19-20)12-2-4-13(5-3-12)22-17-14-8-11-21-16(14)7-9-18-17/h2-11H,1H3
SMILES Code
CN1N=CC=C1C(C=C2)=CC=C2OC3=NC=CC4=C3C=CO4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part of 40 years. All known D1-selective agonists are catecholamines that bring about receptor desensitization and undergo rapid metabolism, thus limiting their utility as a therapeutic for chronic illness such as schizophrenia and Parkinson's disease

Preparing Stock Solutions

The following data is based on the product molecular weight 291.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Davoren JE, Nason DM, Coe J, Dlugolenski K, Helal CJ, Harris AR, LaChapelle E, Liang S, Liu Y, O'Connor RE, Orozco CC, Rai BK, Salafia M, Samas BM, Xu W, Kozak R, Gray D. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018 Nov 15. doi: 10.1021/acs.jmedchem.8b01622. [Epub ahead of print] PubMed PMID: 30431269.