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MedKoo Cat#: 465857 | Name: AEC5

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AEC5 is a novel antifungal peptoid.

Chemical Structure

AEC5
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465857

Name: AEC5

CAS#: unknown

Chemical Formula: C28H51N5O4

Exact Mass: 521.3941

Molecular Weight: 521.75

Elemental Analysis: C, 64.46; H, 9.85; N, 13.42; O, 12.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AEC5; AEC-5; AEC 5;
IUPAC/Chemical Name
N-(2-amino-2-oxoethyl)-2-(N-(4-aminobutyl)-2-(tridecylamino)acetamido)-N-(furan-2-ylmethyl)acetamide
InChi Key
CSDSWZLNBUIVHA-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H51N5O4/c1-2-3-4-5-6-7-8-9-10-11-13-18-31-21-27(35)32(19-14-12-17-29)24-28(36)33(23-26(30)34)22-25-16-15-20-37-25/h15-16,20,31H,2-14,17-19,21-24,29H2,1H3,(H2,30,34)
SMILES Code
O=C(N(CC(N)=O)CC1=CC=CO1)CN(CCCCN)C(CNCCCCCCCCCCCCC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 521.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Spicer SK, Subramani A, Aguila AL, Green RM, McClelland EE, Bicker KL. Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers. 2019 Jun;110(6):e23276. doi: 10.1002/bip.23276. Epub 2019 Apr 2. PMID: 30938841; PMCID: PMC6660985. 2: Middleton MP, Armstrong SA, Bicker KL. Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3514-3519. doi: 10.1016/j.bmcl.2018.10.001. Epub 2018 Oct 3. PMID: 30297282; PMCID: PMC6246776. 3: Corson AE, Armstrong SA, Wright ME, McClelland EE, Bicker KL. Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. 2016 Oct 3;7(12):1139-1144. doi: 10.1021/acsmedchemlett.6b00338. PMID: 27994753; PMCID: PMC5150681. 4: Prokopov VA, Nekrasova LS, Mudryĭ IV. Toksiko-gigienicheskaia kharakteristika novykh sinteticheskikh organicheskikh flokuliantov AES-5, AES-7 i AES-10 [The toxic and hygienic characteristics of the new synthetic organic flocculants AES-5, AES-7 and AES-10]. Lik Sprava. 2000 Mar;(2):15-9. Russian. PMID: 10862467.