Meclocycline sulfosalicylate salt | CAS# 73816-42-9 | Antibiotic

MedKoo Cat#: 574477 | Name: Meclocycline sulfosalicylate salt

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meclocycline sulfosalicylate salt is a tetracycline antibiotic that is topically used for skin infections and irritations.

Chemical Structure

Meclocycline sulfosalicylate salt

CAS#73816-42-9

Theoretical Analysis

MedKoo Cat#: 574477

Name: Meclocycline sulfosalicylate salt

CAS#: 73816-42-9

Chemical Formula: C29H27ClN2O14S

Exact Mass: 694.0872

Molecular Weight: 695.05

Elemental Analysis: C, 50.11; H, 3.92; Cl, 5.10; N, 4.03; O, 32.23; S, 4.61

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 290.00	2 Weeks

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Related CAS #

2013-58-3

Synonym

Meclocycline sulfosalicylate salt; Meclan; Mecloderm; Meclutin; Traumatociclina

IUPAC/Chemical Name

2-Hydroxy-5-sulfo-benzoic Acid (4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide

InChi Key

FYSVKUUNXYGFLA-CCHMMTNSSA-N

InChi Code

InChI=1S/C22H21ClN2O8.C7H6O6S/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30;8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32);1-3,8H,(H,9,10)(H,11,12,13)/t10-,14-,15+,17+,22+;/m1./s1

SMILES Code

O=C(O)C1=CC(S(=O)(O)=O)=CC=C1O.O=C(C(C2=O)=C(O)[C@@H](N(C)C)[C@]3([H])[C@@H](O)[C@]4([H])C(C5=C(C(C4=C(O)[C@@]32O)=O)C(O)=CC=C5Cl)=C)N

Appearance

Off-White to Beige Solid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris.

In vitro activity:

TBD

In vivo activity:

In a screen of 2000 compounds, six were found to produce significant protection of C. elegans from delayed death. Four of the compounds were tested in an ex vivo mouse heart ischemia/reperfusion model and two, meclocycline and 3-amino-1,2,4-triazole, significantly reduced infarction size. Reference: PLoS One. 2017 Apr 20;12(4):e0176061. https://pubmed.ncbi.nlm.nih.gov/28426808/

	Solvent	mg/mL	mM
Solubility
	DMSO	250.0	359.69

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 695.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Sun CL, Zhang H, Liu M, Wang W, Crowder CM. A screen for protective drugs against delayed hypoxic injury. PLoS One. 2017 Apr 20;12(4):e0176061. doi: 10.1371/journal.pone.0176061. PMID: 28426808; PMCID: PMC5398677.

In vitro protocol:

TBD

In vivo protocol: