MedKoo Cat#: 577684 | Name: Montelukast alcohol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Montelukast alcohol is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.

Chemical Structure

Montelukast alcohol
Montelukast alcohol
CAS#287930-77-2

Theoretical Analysis

MedKoo Cat#: 577684

Name: Montelukast alcohol

CAS#: 287930-77-2

Chemical Formula: C29H28ClNO2

Exact Mass: 457.1809

Molecular Weight: 457.99

Elemental Analysis: C, 76.05; H, 6.16; Cl, 7.74; N, 3.06; O, 6.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Montelukast alcohol, Montelukast sodium intermediate MK5
IUPAC/Chemical Name
(alphaS)-alpha-(3-((1E)-2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-2-(1-hydroxy-1-methylethyl)benzenepropanol
InChi Key
ZSHIDKYITZZTLA-FCPABOFRSA-N
InChi Code
InChI=1S/C29H28ClNO2/c1-29(2,33)26-9-4-3-7-21(26)13-17-28(32)23-8-5-6-20(18-23)10-15-25-16-12-22-11-14-24(30)19-27(22)31-25/h3-12,14-16,18-19,28,32-33H,13,17H2,1-2H3/b15-10+/t28-/m0/s1
SMILES Code
CC(C)(O)c1ccccc1CC[C@H](O)c2cccc(\C=C\c3ccc4ccc(Cl)cc4n3)c2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bush A. Montelukast in paediatric asthma: where we are now and what still needs to be done? Paediatr Respir Rev. 2015 Mar;16(2):97-100. doi: 10.1016/j.prrv.2014.10.007. Epub 2014 Dec 12. Review. PubMed PMID: 25499571. 2: Calapai G, Casciaro M, Miroddi M, Calapai F, Navarra M, Gangemi S. Montelukast-induced adverse drug reactions: a review of case reports in the literature. Pharmacology. 2014;94(1-2):60-70. doi: 10.1159/000366164. Epub 2014 Sep 2. Review. PubMed PMID: 25196099. 3: Hon KL, Leung TF, Leung AK. Clinical effectiveness and safety of montelukast in asthma. What are the conclusions from clinical trials and meta-analyses? Drug Des Devel Ther. 2014 Jun 26;8:839-50. doi: 10.2147/DDDT.S39100. eCollection 2014. Review. PubMed PMID: 25061277; PubMed Central PMCID: PMC4079631. 4: Zhang HP, Jia CE, Lv Y, Gibson PG, Wang G. Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis. Allergy Asthma Proc. 2014 Jul-Aug;35(4):278-87. doi: 10.2500/aap.2014.35.3745. Review. PubMed PMID: 24992547. 5: Montelukast for Sleep Apnea: A Review of the Clinical Effectiveness, Cost Effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jan 17. Available from http://www.ncbi.nlm.nih.gov/books/NBK195647/ PubMed PMID: 24741731.