DX3-213B is a potent Oxidative Phosphorylation Inhibitor (MIA PaCa-2 GI50 = 11 nM) for the Treatment of Pancreatic Cancer. DX3-213B disrupts adenosine triphosphate (ATP) generation, inhibits complex I function, and results in the growth inhibition of pancreatic cancer cells in the low nanomolar range. Importantly, the oral administration of DX3-213B resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity.
MedKoo Cat#: 465831
Name: DX3-213B
CAS#: 2749555-66-4
Chemical Formula: C20H28F2N2O5S2
Exact Mass: 478.1408
Molecular Weight: 478.57
Elemental Analysis: C, 50.20; H, 5.90; F, 7.94; N, 5.85; O, 16.72; S, 13.40
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 2.0 | 4.18 | |
| DMSO | 3.0 | 6.27 | |
| Ethanol | 2.0 | 4.18 |
The following data is based on the product molecular weight 478.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
