Synonym
L 12407; L-12407; L12407; Ipronidazole-OH;
IUPAC/Chemical Name
2-(1-methyl-5-nitro-1H-imidazol-2-yl)propan-2-ol
InChi Key
DTHPMNDYKOSVFR-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H11N3O3/c1-7(2,11)6-8-4-5(9(6)3)10(12)13/h4,11H,1-3H3
SMILES Code
OC(C)(C)C1=NC=C([N+]([O-])=O)N1C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
185.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Lin Z, Zhen Z, Chen C, Li Y, Luo C, Zhong L, Hu H, Li J, Zhang Y, Liang Y, Yang J, Zhang D. Rhizospheric effects on atrazine speciation and degradation in laterite soils of Pennisetum alopecuroides (L.) Spreng. Environ Sci Pollut Res Int. 2018 May;25(13):12407-12418. doi: 10.1007/s11356-018-1468-6. Epub 2018 Feb 19. PubMed PMID: 29460244.
2: Chen J, Qian Y, Li H, Cheng Y, Zhao M. The reduced bioavailability of copper by nano-TiO₂ attenuates the toxicity to Microcystis aeruginosa. Environ Sci Pollut Res Int. 2015 Aug;22(16):12407-14. doi: 10.1007/s11356-015-4492-9. Epub 2015 Apr 23. PubMed PMID: 25903177.
3: Das LK, Kadam RM, Bauzá A, Frontera A, Ghosh A. Differences in nuclearity, molecular shapes, and coordination modes of azide in the complexes of Cd(II) and Hg(II) with a "metalloligand" [CuL] (H2L = N,N'-bis(salicylidene)-1,3-propanediamine): characterization in solid and in solutions, and theoretical calculations. Inorg Chem. 2012 Nov 19;51(22):12407-18. doi: 10.1021/ic301773h. Epub 2012 Nov 6. PubMed PMID: 23131113.
4: Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR. Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem. 2011 Apr 8;286(14):12407-16. doi: 10.1074/jbc.M110.191783. Epub 2011 Jan 25. PubMed PMID: 21266572; PubMed Central PMCID: PMC3069444.
