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MedKoo Cat#: 461618 | Name: S 15261

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S 15261 is a new oral anti-hyperglycemic agent that increases insulin sensitivity in various insulin-resistant animal models.

Chemical Structure

S 15261
S 15261
CAS#159978-02-6

Theoretical Analysis

MedKoo Cat#: 461618

Name: S 15261

CAS#: 159978-02-6

Chemical Formula: C36H35F3N2O4

Exact Mass: 616.2549

Molecular Weight: 616.68

Elemental Analysis: C, 70.12; H, 5.72; F, 9.24; N, 4.54; O, 10.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
S 15261; S-15261; S15261;
IUPAC/Chemical Name
2-((2-methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate
InChi Key
ASWYZRRXMGAWGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C36H35F3N2O4/c1-44-33(26-7-6-8-27(21-26)36(37,38)39)23-40-19-20-45-35(43)25-15-13-24(14-16-25)17-18-41-34(42)22-32-30-11-4-2-9-28(30)29-10-3-5-12-31(29)32/h2-16,21,32-33,40H,17-20,22-23H2,1H3,(H,41,42)
SMILES Code
O=C(OCCNCC(OC)C1=CC=CC(C(F)(F)F)=C1)C2=CC=C(CCNC(CC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 616.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Duhault J, Berger S, Boulanger M, Della Zuana O, Lacour F, Wierzbicki M. General pharmacology of S 15261, a new concept for treatment of diabetes. Arzneimittelforschung. 1998 Jul;48(7):734-44. PubMed PMID: 9706374. 2: Caüzac M, Kohl C, Girard J, Pégorier JP. S-15261, a new anti-hyperglycemic agent, reduces hepatic glucose production through direct and insulin-sensitizing effects. Biochem Pharmacol. 2005 Aug 15;70(4):527-34. PubMed PMID: 15993851. 3: Marquié G, Duhault J, Espinal J, Petkov P, Jablenska R, Khallayoun S, Bennani N. S 15261, a novel agent for the treatment of insulin resistance. Studies on Psammomys obesus. Effect on pancreatic islets of insulin resistant animals. Cell Mol Biol (Noisy-le-grand). 1997 Mar;43(2):243-51. PubMed PMID: 9130608. 4: Pickavance LC, Wilding JP. Effects of S 15511, a therapeutic metabolite of the insulin-sensitizing agent S 15261, in the Zucker Diabetic Fatty rat. Diabetes Obes Metab. 2007 Jan;9(1):114-20. PubMed PMID: 17199726. 5: Marquié G, El Madani T, Solera ML, Duhault J, Espinal J, Khallayoun S, Bennani N. S15261, a novel agent for the treatment of insulin resistance. Studies on Psammomys obesus. Life Sci. 1997;61(18):1741-53. PubMed PMID: 9365221. 6: Duhault J, Lacour F, Boulanger M, Della-Zuana O, Ravel D, Wierzbicki M, Espinal J. S15261, a new compound for the treatment of the insulin resistance syndrome. Diabetologia. 1994 Oct;37(10):969-75. PubMed PMID: 7851691. 7: Espinal J, Lacour F, Berger S, Duhault J. S15261 antagonises amylin-induced impaired glucose tolerance. FEBS Lett. 1995 Jul 10;368(1):36-8. PubMed PMID: 7615084. 8: Russell JC, Ravel D, Pégorier JP, Delrat P, Jochemsen R, O'Brien SF, Kelly SE, Davidge ST, Brindley DN. Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat. J Pharmacol Exp Ther. 2000 Nov;295(2):753-60. PubMed PMID: 11046115.

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