ZB-S-29 is a highly efficient SHP2 degrader with a DC50 of 6.02 nM. ZB-S-29 effectively induced the degradation of SHP2 protein in a time and dose-dependent manner with a DC50 of 6.02 nM in MV4;11 cells, and induced more than 90% SHP2 degradation at 500 nM after 24 h of treatment. Moreover, it exhibited significant cell proliferation inhibition in MV4;11 cells and induced apparent G1 phase arrest or apoptosis in a dose-dependent manner.
MedKoo Cat#: 465812
Name: ZB-S-29
CAS#: 2639330-26-8 (free base)
Chemical Formula: C46H59ClN10O10S
Exact Mass: 978.3825
Molecular Weight: 979.55
Elemental Analysis: C, 56.40; H, 6.07; Cl, 3.62; N, 14.30; O, 16.33; S, 3.27
The following data is based on the product molecular weight 979.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
