MedKoo Cat#: 597028 | Name: D-loop peptide, synthetic

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D-loop peptide, synthetic is an antigenic peptide which cyclise through a peptide bond between the side chain carboxylic group of Asp10 and the terminal amide of the peptide; designed to mimic an antigenic loop of the haemagglutinin.

Chemical Structure

D-loop peptide, synthetic
D-loop peptide, synthetic
CAS#130304-73-3

Theoretical Analysis

MedKoo Cat#: 597028

Name: D-loop peptide, synthetic

CAS#: 130304-73-3

Chemical Formula: C53H76N16O16S

Exact Mass: 1224.5346

Molecular Weight: 1225.34

Elemental Analysis: C, 51.95; H, 6.25; N, 18.29; O, 20.89; S, 2.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
D-loop peptide, synthetic; D-Loop protein;
IUPAC/Chemical Name
(S)-4-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-3-((S)-2-((S)-2-((S)-2-(2-((S)-1-(((S,E)-2-((S)-6-amino-2-((R)-2-amino-3-mercaptopropanamido)hexanamido)-5-guanidinopent-3-enoyl)glycyl)pyrrolidine-2-carboxamido)acetamido)-3-hydroxypropanamido)-3-carboxypropanamido)-3-phenylpropanamido)-4-oxobutanoic acid
InChi Key
HYWFEJXPLXSMDO-ANOYAANVSA-N
InChi Code
InChI=1S/C53H76N16O16S/c54-18-8-7-15-33(63-45(78)31(55)28-86)47(80)64-32(16-9-19-59-53(57)58)46(79)61-26-41(72)69-20-10-17-39(69)52(85)60-25-40(71)62-38(27-70)51(84)68-37(24-43(75)76)50(83)66-35(22-30-13-5-2-6-14-30)48(81)67-36(23-42(73)74)49(82)65-34(44(56)77)21-29-11-3-1-4-12-29/h1-6,9,11-14,16,31-39,70,86H,7-8,10,15,17-28,54-55H2,(H2,56,77)(H,60,85)(H,61,79)(H,62,71)(H,63,78)(H,64,80)(H,65,82)(H,66,83)(H,67,81)(H,68,84)(H,73,74)(H,75,76)(H4,57,58,59)/b16-9+/t31-,32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
SMILES Code
O=C(N)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H]1CCCN1C(CNC([C@@H](NC([C@@H](NC([C@@H](N)CS)=O)CCCCN)=O)/C=C/CNC(N)=N)=O)=O)=O)=O)CO)=O)CC(O)=O)=O)Cc2ccccc2)=O)CC(O)=O)=O)Cc3ccccc3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,225.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu SA, Jiang RS, Wang WY, Lin JC. Somatic mutations in the D-loop of mitochondrial DNA in head and neck squamous cell carcinoma. Head Neck. 2015 Jun;37(6):878-83. doi: 10.1002/hed.23680. Epub 2014 Jun 27. PubMed PMID: 24976238. 2: Bellis C, Ashton KJ, Freney L, Blair B, Griffiths LR. A molecular genetic approach for forensic animal species identification. Forensic Sci Int. 2003 Jul 8;134(2-3):99-108. PubMed PMID: 12850402. 3: Del Bo R, Bordoni A, Martinelli Boneschi F, Crimi M, Sciacco M, Bresolin N, Scarlato G, Comi GP. Evidence and age-related distribution of mtDNA D-loop point mutations in skeletal muscle from healthy subjects and mitochondrial patients. J Neurol Sci. 2002 Oct 15;202(1-2):85-91. PubMed PMID: 12220698. 4: Montiel R, Malgosa A, Francalacci P. Authenticating ancient human mitochondrial DNA. Hum Biol. 2001 Oct;73(5):689-713. PubMed PMID: 11758690. 5: Tsai LC, Lin CY, Lee JC, Chang JG, Linacre A, Goodwin W. Sequence polymorphism of mitochondrial D-loop DNA in the Taiwanese Han population. Forensic Sci Int. 2001 Jun 15;119(2):239-47. PubMed PMID: 11376990. 6: Garcia MI, Perez M, Caruso M, Sthandier O, Ferreira R, Cermola M, Macchia C, Amati P. A mutation in the DE loop of the VP1 protein that prevents polyomavirus transcription and replication. Virology. 2000 Jul 5;272(2):293-301. PubMed PMID: 10873772. 7: Lagerkvist A, Stewart J, Lagerström-Fermér M, Landegren U. Manifold sequencing: efficient processing of large sets of sequencing reactions. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2245-9. PubMed PMID: 8134382; PubMed Central PMCID: PMC43347. 8: Suzuki R, Kemp SJ, Teale AJ. Polymerase chain reaction analysis of mitochondrial DNA polymorphism in N'Dama and Zebu cattle. Anim Genet. 1993 Oct;24(5):339-43. PubMed PMID: 7904799. 9: Kieffer B, Koehl P, Lefèvre JF. Modelling the dynamics of an antigenic peptide using NMR relaxation data. Biochimie. 1992 Sep-Oct;74(9-10):815-24. PubMed PMID: 1467341.