MedKoo Cat#: 471074 | Name: W146 TFA
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

W146 is a sphingosine-1-phosphate (S1P1) antagonist that enhances capillary leakage and restores lymphocyte egress in vivo.

Chemical Structure

W146 TFA
W146 TFA
CAS#909725-62-8 (TFA)

Theoretical Analysis

MedKoo Cat#: 471074

Name: W146 TFA

CAS#: 909725-62-8 (TFA)

Chemical Formula: C18H28F3N2O6P

Exact Mass: 0.0000

Molecular Weight: 456.40

Elemental Analysis: C, 47.37; H, 6.18; F, 12.49; N, 6.14; O, 21.03; P, 6.79

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
W-146 (trifluoroacetate salt); W 146 (trifluoroacetate salt); W-146 TFA; W 146 TFA;
IUPAC/Chemical Name
[3R-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate)
InChi Key
JDWCNCPWPLHFEX-XFULWGLBSA-N
InChi Code
InChI=1S/C16H27N2O4P.C2HF3O2/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;3-2(4,5)1(6)7/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);(H,6,7)/t15-;/m1./s1
SMILES Code
O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O.O=C(O)C(F)(F)F
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 456.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954 2. Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635