Synonym
A 65317; A65317; A-65317
IUPAC/Chemical Name
1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-2-(3-ethyl-2-oxo-5-oxazolidinyl)-2-hydroxyethyl)-alpha-((5-methyl-1,4-dioxo-2-(phenylmethyl)-8,10,13-trioxa-5-azatetradec-1-yl)amino)-, (5S-(5R*(1R*(R*(S*)),2S*)))-
InChi Key
JZRFAIHFMIECQR-JAUPOCBBSA-N
InChi Code
InChI=1S/C38H58N6O9/c1-4-44-24-33(53-38(44)49)35(46)31(20-28-13-9-6-10-14-28)41-37(48)32(22-30-23-39-25-40-30)42-36(47)29(19-27-11-7-5-8-12-27)21-34(45)43(2)15-16-51-26-52-18-17-50-3/h5,7-8,11-12,23,25,28-29,31-33,35,46H,4,6,9-10,13-22,24,26H2,1-3H3,(H,39,40)(H,41,48)(H,42,47)/t29-,31+,32-,33+,35?/m1/s1
SMILES Code
O=C(N[C@@H](CC1CCCCC1)C([C@@H]2CN(CC)C(O2)=O)O)[C@H](NC([C@H](CC3=CC=CC=C3)CC(N(C)CCOCOCCOC)=O)=O)CC4=CNC=N4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
742.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Verburg KM, Kadam JR, Young GA, Rosenberg SH, Kleinert HD. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259(1 Pt 2):R7-14. PubMed PMID: 2197881.
2: Dayton BD, Stein HH, Cohen J, Baker WR, Boyd SA, Condon SL, Donner BG, Fung AK, Luly JR, Rosenberg SH, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clin Chem. 1992 Nov;38(11):2239-43. PubMed PMID: 1330373.
3: Kim J, Hughbanks T. Synthesis and structures of new ternary aluminum chalcogenides: LiAlSe2, alpha-LiAlTe2, and beta-LiAlTe2. Inorg Chem. 2000 Jul 10;39(14):3092-7. PubMed PMID: 11196906.
