YWN-00640 is a novel inhibitor of PD-1/PD-L1 (IC50 value of 56.58 nM), dose-dependently promoting HepG2 cell death in a co-culture model of HepG2/hPD-L1 and Jurkat T cells, effectively inhibiting tumor growth (TGI of 76.4% at 90 mg/kg) in an immune checkpoint humanized mouse model with no obvious toxicity.
MedKoo Cat#: 465546
Name: YWN-00640
CAS#: unknown
Chemical Formula: C35H33ClF3NO5
Exact Mass: 639.1999
Molecular Weight: 640.10
Elemental Analysis: C, 65.68; H, 5.20; Cl, 5.54; F, 8.90; N, 2.19; O, 12.50
The following data is based on the product molecular weight 640.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
