MedKoo Cat#: 407500 | Name: PZ-285

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PZ-285 is a potent anticancer agent. Pz 285 has excellent potential as a chemotherapeutic anticancer agent. The in vivo activity of Pz 285 improves survival, inhibits primary tumor regrowth, and inhibits lung tumor metastasis compared to vehicle control animals; Pz 285 has similar antitumor activity to the clinically active agent Dox.

Chemical Structure

PZ-285
PZ-285
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 407500

Name: PZ-285

CAS#: Unknown

Chemical Formula: C42H50N8O14

Exact Mass: 890.3446

Molecular Weight: 890.90

Elemental Analysis: C, 56.62; H, 5.66; N, 12.58; O, 25.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PZ-285; PZ 285; PZ285; Pz-285; Pz 285; Pz285; Porphyrazine Diol; H2Pz(A3B)
IUPAC/Chemical Name
N/A
InChi Key
PURPDMVLMICIQP-GIEDQAFWSA-N
InChi Code
InChI=1S/C42H50N8O14/c1-37(53-7)39(3,55-9)61-25-23(59-37)31-44-29-21-19(15-17-51)13-14-20(16-18-52)22(21)30(43-29)45-32-24-26(62-40(4,56-10)38(2,54-8)60-24)34(47-32)49-36-28-27(35(50-36)48-33(25)46-31)63-41(5,57-11)42(6,58-12)64-28/h13-14,51-52H,15-18H2,1-12H3,(H2,43,44,45,46,47,48,49,50)/t37-,38-,39-,40-,41-,42-/m1/s1
SMILES Code
C[C@@]([C@](C)(OC)O1)(OC)OC(/C2=N/C3=N/C(C4=C3O[C@@](C)(OC)[C@](C)(OC)O4)=N\5)=C1/C(N2)=N/C(C6=C/7C(CCO)=CC=C6CCO)=NC7=N/C8=C(O[C@@](C)(OC)[C@](C)(OC)O9)C9=C5N8
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Porphyrazines (Pzs) are tetrapyrrolic macrocycles made by a synthetic pathway that allows for heteroatom substitution. (S, N, O) in the β-pyrrole positions. Heteroatom functionalized Pzs have been recently examined as PDT agents, with some N atom functionalized macrocycles exhibiting remarkably high singlet oxygen quantum yields (ΦΔ > 50%). Pz 285 showed poor singlet oxygen quantum yield (ΦΔ < 1%).

Preparing Stock Solutions

The following data is based on the product molecular weight 890.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice Irawati K. Kandela, Katherine J. McAuliffe, Lauren E. Cochran, Anthony G. M. Barrett, Brian M. Hoffman, Andrew P. Mazar, and Evan R. Trivedi Publication Date (Web): June 29, 2017 (Letter). DOI: 10.1021/acsmedchemlett.7b00063