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MedKoo Cat#: 571009 | Name: A-10255

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A-10255 is a complex of thiopeptide antibiotics from Streptomyces gardneri.

Chemical Structure

A-10255
A-10255
CAS#144376-84-1

Theoretical Analysis

MedKoo Cat#: 571009

Name: A-10255

CAS#: 144376-84-1

Chemical Formula: C40H35N13O10S3

Exact Mass: 953.1792

Molecular Weight: 953.98

Elemental Analysis: C, 50.36; H, 3.70; N, 19.09; O, 16.77; S, 10.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
A 10255, A10255, A-10255
IUPAC/Chemical Name
(12Z,32Z,9Z)-9-ethylidene-6-(1-hydroxyethyl)-17-methyl-21,24-dimethylene-4,7,11,15,19,22-hexaoxo-5,8,12,16,20,23-hexaaza-1(4,2),10(2,5)-dioxazola-3(2,4),14,18(2,5)-trithiazola-2(2,3)-pyridinacyclotetracosaphane-26-carboxamide
InChi Key
VMEMFKILQLCGSB-IOXNKQMXSA-N
InChi Code
InChI=1S/C40H35N13O10S3/c1-6-20-38-44-9-24(63-38)33(58)43-12-27-42-10-25(65-27)34(59)48-17(4)39-45-11-26(66-39)35(60)46-15(2)31(56)47-16(3)37-51-22(13-62-37)29-19(7-8-21(49-29)30(41)55)40-52-23(14-64-40)32(57)53-28(18(5)54)36(61)50-20/h6-11,13-14,17-18,28,54H,2-3,12H2,1,4-5H3,(H2,41,55)(H,43,58)(H,46,60)(H,47,56)(H,48,59)(H,50,61)(H,53,57)/b20-6-
SMILES Code
C/C=C1c2oc(C(NCc3sc(C(NC(C)c4sc(C(NC(C(NC(c5occ(c6nc(C(N)=O)ccc6c7scc(C(NC(C(O)C)C(N/1)=O)=O)n7)n5)=C)=O)=C)=O)cn4)=O)cn3)=O)cn2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 953.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Miyoki S, Ohashi M, Waseda K, Karoji H, Tomaru T. Manufacture of a 10-km-scale radius-of-curvature surface by use of a thin-film coating technique. Opt Lett. 2005 Jun 1;30(11):1399-401. PubMed PMID: 15981546. 2: Favret ME, Boeck LD. Effect of cobalt and cyanocobalamin on biosynthesis of A10255, a thiopeptide antibiotic complex. J Antibiot (Tokyo). 1992 Nov;45(11):1809-11. PubMed PMID: 1468992. 3: Favret ME, Paschal JW, Elzey TK, Boeck LD. Biosynthesis of thiopeptide antibiotic A10255: incorporation of isotopically-labeled precursors. J Antibiot (Tokyo). 1992 Sep;45(9):1499-511. PubMed PMID: 1429236. 4: Boeck LD, Berry DM, Mertz FP, Wetzel RW. A10255, a complex of novel growth-promoting thiopeptide antibiotics produced by a strain of Streptomyces gardneri. Taxonomy and fermentation studies. J Antibiot (Tokyo). 1992 Aug;45(8):1222-30. PubMed PMID: 1399842. 5: Tung RS, Kung L Jr. In vitro effects of a thiopeptide and monensin on ruminal fermentation of soluble carbohydrates. J Dairy Sci. 1993 Apr;76(4):1083-90. PubMed PMID: 8486839. 6: Boeck LD, Favret ME, Wetzel RW. Biosynthesis of thiopeptide antibiotic A10255 in stirred reactors using a chemically defined medium supplemented with continuous nutrient feeds. J Antibiot (Tokyo). 1992 Aug;45(8):1278-85. PubMed PMID: 1399849. 7: Tung RS, Kung L Jr, Slyter LL. In vitro effects of the thiopeptide A10255 on ruminal fermentation and microbial populations. J Dairy Sci. 1992 Sep;75(9):2494-503. PubMed PMID: 1452854.

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Acetiromate

Acetiromate