Bz-IEGR-pNA acetate | CAS# 1325307-57-0 | Colorimetric Substrate

MedKoo Cat#: 574003 | Name: Bz-IEGR-pNA acetate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bz-IEGR-pNA acetate is a colorimetric substrate for Factor Xa. Factor Xa preferentially binds to and cleaves the Ile-Glu-Gly-Arg (IEGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.

Chemical Structure

Bz-IEGR-pNA acetate

CAS#1325307-57-0

Theoretical Analysis

MedKoo Cat#: 574003

Name: Bz-IEGR-pNA acetate

CAS#: 1325307-57-0

Chemical Formula: C34H47N9O11

Exact Mass: 0.0000

Molecular Weight: 757.80

Elemental Analysis: C, 53.89; H, 6.25; N, 16.64; O, 23.22

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Synonym

Bz-IEGR-pNA acetate; Bz-Ile-Glu-Gly-Arg-pNA; Bz-Ile-Glu-Gly-Arg-p-nitroanilide; Factor Xa Chromogenic Substrate

IUPAC/Chemical Name

N-benzoyl-L-isoleucyl-L-α-glutamylglycyl-N-(4-nitrophenyl)-L-argininamide, monoacetate

InChi Key

ITXQNZUGLZNGBM-PJSBSAQXSA-N

InChi Code

InChI=1S/C32H43N9O9.C2H4O2/c1-3-19(2)27(40-28(45)20-8-5-4-6-9-20)31(48)39-24(15-16-26(43)44)29(46)36-18-25(42)38-23(10-7-17-35-32(33)34)30(47)37-21-11-13-22(14-12-21)41(49)50;1-2(3)4/h4-6,8-9,11-14,19,23-24,27H,3,7,10,15-18H2,1-2H3,(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,40,45)(H,43,44)(H4,33,34,35);1H3,(H,3,4)/t19-,23-,24-,27-;/m0./s1

SMILES Code

O=C([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC([C@](NC(C1=CC=CC=C1)=O)([H])[C@@H](C)CC)=O)CCC(O)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2.CC(O)=O

Appearance

A crystalline solid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

λmax: 224, 314 nm

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 757.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Aruell, L., Friberger, P., Karlsson, G., et al. A new sensitive and highly specific chromogenic peptide substrate for factor Xa. Thromb. Res. 11(5), 595-609 (1977).