Tozasertib lactate | CAS# 899827-04-4 | Aurora kinase inhibitor

MedKoo Cat#: 577518 | Name: Tozasertib lactate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tozasertib lactate is a potent and selective small-molecule inhibitor of the Aurora kinases which suppresses tumor growth by inducing apoptosis in tumor cells in which Aurora kinases are overexpressed.

Chemical Structure

Tozasertib lactate

CAS#899827-04-4 (lactate)

Theoretical Analysis

MedKoo Cat#: 577518

Name: Tozasertib lactate

CAS#: 899827-04-4 (lactate)

Chemical Formula: C26H34N8O4S

Exact Mass: 554.2424

Molecular Weight: 554.67

Elemental Analysis: C, 56.30; H, 6.18; N, 20.20; O, 11.54; S, 5.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

639089-54-6 (free base) 899827-04-4 (lactate)

Synonym

Tozasertib lactate; MK-0457 lactate; MK 0457 lactate; MK0457 lactate; VX-680 lactate; VX 680 lactate; VX680 lactate

IUPAC/Chemical Name

Propanoic acid, 2-hydroxy-, (2S)-, compd. with N-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)cyclopropanecarboxamide

InChi Key

MHFUWOIXNMZFIW-WNQIDUERSA-N

InChi Code

InChI=1S/C23H28N8OS.C3H6O3/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16;1-2(4)3(5)6/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29);2,4H,1H3,(H,5,6)/t;2-/m.0/s1

SMILES Code

C[C@H](O)C(=O)O.CN1CCN(CC1)c2cc(Nc3cc(C)[nH]n3)nc(Sc4ccc(NC(=O)C5CC5)cc4)n2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 554.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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