R-82913, also known as 9-Cmbib; NSC 637653, 9-Cl-Tibo, is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold more potent than AZT-TP in the inhibition of HIV-1 reverse transcriptase in an assay. R82913 has no effect on the replication of HIV-2 in CEM cells and does not inhibit the reverse transcriptase from this virus.
MedKoo Cat#: 526953
Name: R-82913
CAS#: 126347-69-1
Chemical Formula: C16H20ClN3S
Exact Mass: 321.1066
Molecular Weight: 321.87
Elemental Analysis: C, 59.71; H, 6.26; Cl, 11.01; N, 13.06; S, 9.96
The following data is based on the product molecular weight 321.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
