XY-06-007 is a selective "bump-and-hole" PROTAC degrader targeting the engineered BRD4BD1L94V fusion protein. It achieves a DC₅₀ of 10 nM within 6 hours, inducing proteasomal degradation without affecting wild-type BRD4. The compound links a cereblon (CRBN) E3 ligase ligand to a modified (+)-JQ1 derivative, selectively binding the L94V mutant bromodomain.
MedKoo Cat#: 465664
Name: XY-06-007
CAS#: unknown
Chemical Formula: C41H41ClN8O8
Exact Mass: 808.2736
Molecular Weight: 809.28
Elemental Analysis: C, 60.85; H, 5.11; Cl, 4.38; N, 13.85; O, 15.82
The following data is based on the product molecular weight 809.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
