MedKoo Cat#: 526273 | Name: T521

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T521 is a novel specific inhibitor of the PBD of Plk1, but not inhibiting Plk2-3.

Chemical Structure

T521
T521
CAS#891020-54-5

Theoretical Analysis

MedKoo Cat#: 526273

Name: T521

CAS#: 891020-54-5

Chemical Formula: C17H14FNO5S2

Exact Mass: 395.0297

Molecular Weight: 395.42

Elemental Analysis: C, 51.64; H, 3.57; F, 4.80; N, 3.54; O, 20.23; S, 16.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
T521, T 521, T521
IUPAC/Chemical Name
5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)oxazole
InChi Key
MVTLATINKNLPEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14FNO5S2/c1-2-25(20,21)17-16(26(22,23)14-6-4-3-5-7-14)19-15(24-17)12-8-10-13(18)11-9-12/h3-11H,2H2,1H3
SMILES Code
O=S(C1=C(S(=O)(CC)=O)OC(C2=CC=C(F)C=C2)=N1)(C3=CC=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 395.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Archambault V, Normandin K. Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators. Cell Cycle. 2017 May 19:1-5. doi: 10.1080/15384101.2017.1325043. [Epub ahead of print] PubMed PMID: 28521657. 2: Chen Y, Zhang J, Li D, Jiang J, Wang Y, Si S. Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain. Oncotarget. 2017 Jan 3;8(1):1234-1246. doi: 10.18632/oncotarget.13603. PubMed PMID: 27902479; PubMed Central PMCID: PMC5352051. 3: Ben Said M, Abbassi MS, Bianchini V, Sghaier S, Cremonesi P, Romanò A, Gualdi V, Hassen A, Luini MV. Genetic characterization and antimicrobial resistance of Staphylococcus aureus isolated from bovine milk in Tunisia. Lett Appl Microbiol. 2016 Dec;63(6):473-481. doi: 10.1111/lam.12672. Epub 2016 Nov 2. PubMed PMID: 27657910. 4: Birmingham BK, Bujac SR, Elsby R, Azumaya CT, Wei C, Chen Y, Mosqueda-Garcia R, Ambrose HJ. Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect? Eur J Clin Pharmacol. 2015 Mar;71(3):341-55. doi: 10.1007/s00228-014-1801-z. Epub 2015 Feb 12. PubMed PMID: 25673568. 5: Birmingham BK, Bujac SR, Elsby R, Azumaya CT, Zalikowski J, Chen Y, Kim K, Ambrose HJ. Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States. Eur J Clin Pharmacol. 2015 Mar;71(3):329-40. doi: 10.1007/s00228-014-1800-0. Epub 2015 Jan 30. PubMed PMID: 25630984. 6: Chen L, Qian J, Sheng Z, Mao Y. [Analysis of function of the 452 bp sequence proceeding the pgiB gene in Bacillus stearothermophilus]. Wei Sheng Wu Xue Bao. 2002 Apr;42(2):175-80. Chinese. PubMed PMID: 12557393. 7: Lesca G, Ollagnon-Roman E, Lachanat J, Dusser A, Edery P, Jeanpierre M, Plauchu H. [Diagnostic trap and difficulties of genetic counseling in a family with neuromuscular disease carriers]. Arch Pediatr. 2001 Sep;8(9):957-60. French. PubMed PMID: 11582937.