T1117 | CAS#1186195-59-4 | Fluorescent AM25

MedKoo Cat#: 532804 | Name: T1117

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T1117 is a fluorescent form of AM 25. It displays CB1 ligands.

Chemical Structure

T1117

CAS#1186195-59-4

Theoretical Analysis

MedKoo Cat#: 532804

Name: T1117

CAS#: 1186195-59-4

Chemical Formula: C56H53Cl2N7O5

Exact Mass: 973.3485

Molecular Weight: 974.98

Elemental Analysis: C, 68.99; H, 5.48; Cl, 7.27; N, 10.06; O, 8.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

T1117, T 1117, T-1117

IUPAC/Chemical Name

5-[4-[4-[3-[[3',6'-bis(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl]amino]propyl]phenyl]phenyl]-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide

InChi Key

RNAPRXIZPJDYPH-UHFFFAOYSA-N

InChi Code

InChI=1S/C56H53Cl2N7O5/c1-34-51(54(67)61-64-28-7-6-8-29-64)60-65(48-26-20-40(57)31-47(48)58)52(34)38-17-15-37(16-18-38)36-13-11-35(12-14-36)10-9-27-59-53(66)39-19-23-44-43(30-39)55(68)70-56(44)45-24-21-41(62(2)3)32-49(45)69-50-33-42(63(4)5)22-25-46(50)56/h11-26,30-33H,6-10,27-29H2,1-5H3,(H,59,66)(H,61,67)

SMILES Code

O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C4=CC=C(CCCNC(C5=CC=C(C6=C5)C7(C8=C(OC9=C7C=CC(N(C)C)=C9)C=C(N(C)C)C=C8)OC6=O)=O)C=C4)C=C3)=C1C)NN%10CCCCC%10

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 974.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bruno A, Lembo F, Novellino E, Stornaiuolo M, Marinelli L. Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay. Sci Rep. 2014 Jan 20;4:3757. doi: 10.1038/srep03757. PubMed PMID: 24441508; PubMed Central PMCID: PMC3895875. 2: Paul RK, Wnorowski A, Gonzalez-Mariscal I, Nayak SK, Pajak K, Moaddel R, Indig FE, Bernier M, Wainer IW. (R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility. Biochem Pharmacol. 2014 Feb 15;87(4):547-61. doi: 10.1016/j.bcp.2013.11.020. Epub 2013 Dec 16. PubMed PMID: 24355564; PubMed Central PMCID: PMC3935314. 3: Daly CJ, Ross RA, Whyte J, Henstridge CM, Irving AJ, McGrath JC. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010 Feb;159(4):787-96. doi: 10.1111/j.1476-5381.2009.00608.x. Epub 2010 Feb 5. PubMed PMID: 20136833; PubMed Central PMCID: PMC2829204.