Mitapivat, also known as AG348, is a potent, selective allosteric activator of the enzyme pyruvate kinase (PK), specifically the red blood cell isoform PKR. By enhancing PKR activity, Mitapivat increases glycolytic flux, leading to improved ATP production and redox balance, which is particularly beneficial in conditions such as pyruvate kinase deficiency (PKD) and other hemolytic anemias.Mitapivat directly binds to PKR, increasing its enzymatic activity in purified enzyme systems and red blood cell lysates. It enhances the enzyme's affinity for PEP, boosting its catalytic efficiency. Treatment with Mitapivat in vitro leads to reductions in markers of oxidative stress in red blood cells.
MedKoo Cat#: 577460
Name: Mitapivat sulfate
CAS#: 2329710-91-8 (sulfate)
Chemical Formula: C48H54N8O10S3
Exact Mass: 0.0000
Molecular Weight: 999.19
Elemental Analysis: C, 57.70; H, 5.45; N, 11.21; O, 16.01; S, 9.63
The following data is based on the product molecular weight 999.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |